Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.34 |
| ▸ | PDE4A | P27815 | 2/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.34 |
| ▸ | KDM1A | O60341 | 6/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | MAT2A | P31153 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3354619 | 1.00 | ASH1L (0.39) | ASH1LROCK2ALDH1A1HTTMAP3K5 | |
| SCHEMBL3356885 | 0.81 | KDM4E (0.42) | ASH1LROCK2ALDH1A1HTTPDE4A | |
| SCHEMBL3348593 | 0.79 | IRAK4 (0.44) | ALDH1A1HTTSLC6A4 | |
| SCHEMBL15129299 | 0.77 | ALDH1A1 (0.37) | ASH1LALDH1A1HTTMAP3K5PDE4A | |
| SCHEMBL3354536 | 0.74 | OPRM1 (0.36) | ALDH1A1KDM1ASLC6A4 | |
| SCHEMBL3354541 | 0.74 | OPRM1 (0.36) | ALDH1A1KDM1ASLC6A4 | |
| SCHEMBL3358911 | 0.74 | OPRM1 (0.36) | ALDH1A1KDM1ASLC6A4 | |
| SCHEMBL1876500 | 0.67 | TOP2A (0.37) | ASH1LALDH1A1HTTMAT2A | |
| SCHEMBL27527082 | 0.67 | CYP3A4 (0.41) | ALDH1A1HTTMAP3K5 | |
| SCHEMBL20374357 | 0.66 | ALDH1A1 (0.69) | ALDH1A1HTTSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2141163-A1 | Substituted thiazolidinones, their production and utilisation as medicine | Bayer Schering Pharma AG (DE) | 2010-01-06 | — | — | EP | disclosed |