Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | SRC | P12931 | 2/20 | 0.44 |
| ▸ | ABL2 | P42684 | 2/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
| ▸ | HTR1F | P30939 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 3/20 | 0.38 |
| ▸ | CDK9 | P50750 | 3/20 | 0.38 |
| ▸ | CASP7 | P55210 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3355552 | 0.86 | DRD2 (0.42) | ABL1EGFRSRCABL2LCK | |
| SCHEMBL13537340 | 0.84 | DRD2 (0.40) | ABL1EGFRSRCABL2LCK | |
| SCHEMBL3352191 | 0.84 | SCD (0.47) | DRD2SLC6A4HTR1AHTR1DHTR1B | |
| SCHEMBL3357844 | 0.84 | ABL1 (0.44) | ABL1EGFRSRCABL2LCK | |
| SCHEMBL3353063 | 0.83 | HTR7 (0.42) | ABL1EGFRSRCABL2LCK | |
| SCHEMBL3355691 | 0.80 | DRD2 (0.52) | DRD2SLC6A4HTR1AHTR1DHTR1B | |
| SCHEMBL3358885 | 0.78 | DRD2 (0.67) | DRD2SLC6A4HTR1AHTR1DHTR1B | |
| SCHEMBL3352865 | 0.76 | HTR1D (0.51) | DRD2SLC6A4HTR1AHTR1DHTR1B | |
| SCHEMBL3358927 | 0.75 | DRD2 (0.50) | DRD2SLC6A4HTR1AHTR1DHTR1B | |
| SCHEMBL3354522 | 0.75 | GRIN2B (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2141163-A1 | Substituted thiazolidinones, their production and utilisation as medicine | Bayer Schering Pharma AG (DE) | 2010-01-06 | — | — | EP | disclosed |
| EP-2141163-A1 | Substituted thiazolidinones, their production and utilisation as medicine | Bayer Schering Pharma AG (DE) | 2010-01-06 | — | — | EP | disclosed |