Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 3/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.48 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.48 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | EZH2 | Q15910 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | FNTA | P49354 | 1/20 | 0.40 |
| ▸ | FNTB | P49356 | 1/20 | 0.40 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL640968 | 0.84 | SLC6A3 (0.54) | AREGFRERBB2ERBB3ERBB4 | |
| SCHEMBL632218 | 0.81 | CYP3A4 (0.46) | AREGFRERBB2ERBB3ERBB4 | |
| SCHEMBL28696921 | 0.81 | KDM4E (0.54) | ARKDM4EALDH1A1USP2POLB | |
| SCHEMBL3356525 | 0.81 | KDM4E (0.50) | ARKDM4EALDH1A1USP2EZH2 | |
| SCHEMBL5146047 | 0.79 | GAA (0.45) | ARKDM4EALDH1A1USP2EZH2 | |
| SCHEMBL1964539 | 0.79 | CYP3A4 (0.56) | ALDH1A1POLBGAALMNAMAPT | |
| SCHEMBL7025384 | 0.78 | SLC22A12 (0.41) | AREGFRERBB2ERBB3ERBB4 | |
| SCHEMBL7054403 | 0.77 | GAA (0.64) | ARALDH1A1POLBGAASMN1; SMN2 | |
| SCHEMBL11783518 | 0.77 | AR (0.57) | ARKDM4EALDH1A1USP2SLC22A12 | |
| SCHEMBL2748578 | 0.77 | PLAU (0.50) | EGFRERBB2KDM4EALDH1A1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010036910-A1 | HEART PROTECTION BY ADMINISTERING AN AMP-ACTIVATED PROTEIN KINASE ACTIVATOR | OHTA YOSHIKAZU (JP) | 2010-04-01 | — | — | WO | disclosed |