SCHEMBL632218

SCHEMBL632218

Nc1ccc(Oc2ccccc2Cl)c(Cl)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.46
TSHR P16473 1/20 0.46
HPGD P15428 1/20 0.44
SLC6A2 P23975 4/20 0.43
SLC6A3 Q01959 4/20 0.43
SLC6A4 P31645 3/20 0.43
ALDH1A1 P00352 1/20 0.43
GAA P10253 1/20 0.43
ALOX15 P16050 1/20 0.43
HTT P42858 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
RHEB Q15382 1/20 0.42
AR P10275 1/20 0.42
CXCL8 P10145 1/20 0.42
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42
PLA2G7 Q13093 1/20 0.42
PDE7A Q13946 1/20 0.41
SYK P43405 1/20 0.41
LMNA P02545 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1964539 0.89 CYP3A4 (0.56) CYP3A4TSHRHPGDSLC6A2SLC6A3
SCHEMBL22069692 0.87 RHEB (0.45) CYP3A4TSHRHPGDSLC6A2SLC6A3
SCHEMBL2330113 0.85 MEN1 (0.49) CYP3A4TSHRSLC6A2SLC6A3SLC6A4
SCHEMBL25500740 0.85 AR (0.60) CYP3A4TSHRHPGDSLC6A2SLC6A3
SCHEMBL6731188 0.85 ALDH1A1 (0.46) CYP3A4HPGDSLC6A2SLC6A3SLC6A4
SCHEMBL5549544 0.85 AR (0.49) CYP3A4HPGDSLC6A2SLC6A3SLC6A4
SCHEMBL15891019 0.85 SLC6A2 (0.41) CYP3A4TSHRHPGDSLC6A2SLC6A3
SCHEMBL9517127 0.85 CYP3A4 (0.52) CYP3A4TSHRHPGDSLC6A2SLC6A3
SCHEMBL15891143 0.84 CYP3A4 (0.39) CYP3A4TSHRHPGDSLC6A2SLC6A3
SCHEMBL3484572 0.83 ESRRA (0.56) CYP3A4TSHRHPGDALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4097111-B9 PYRIDO[2,3-E]OXAZINE DERIVATIVES AS AGRICULTURAL CHEMICALS GLOBACHEM NV (BE) 2025-10-29 EP disclosed
US-12415815-B2 Pyrido[2,3-e]oxazine derivatives as agricultural chemicals GLOBACHEM NV (BE) 2025-09-16 US disclosed
EP-4097111-B1 PYRIDO[2,3-E]OXAZINE DERIVATIVES AS AGRICULTURAL CHEMICALS GLOBACHEM NV (BE) 2025-07-23 EP disclosed
CN-115427415-B Pyrido [2,3-E ] oxazine derivatives as agrochemicals 环球化学股份有限公司 2024-07-12 CN disclosed
US-20230151023-A1 PYRIDO[2,3-E]OXAZINE DERIVATIVES AS AGRICULTURAL CHEMICALS GLOBACHEM NV (BE) 2023-05-18 US disclosed
US-20230151023-A1 PYRIDO[2,3-E]OXAZINE DERIVATIVES AS AGRICULTURAL CHEMICALS GLOBACHEM NV (BE) 2023-05-18 US disclosed
US-20230151023-A1 PYRIDO[2,3-E]OXAZINE DERIVATIVES AS AGRICULTURAL CHEMICALS GLOBACHEM NV (BE) 2023-05-18 US disclosed
EP-4097111-A1 PYRIDO[2,3-E]OXAZINE DERIVATIVES AS AGRICULTURAL CHEMICALS Globachem NV (BE) 2022-12-07 EP disclosed
CN-115427415-A Pyrido [2,3-E ] oxazine derivatives for use as agrochemicals 环球化学股份有限公司 2022-12-02 CN disclosed
WO-2021151919-A1 PYRIDO[2,3-E]OXAZINE DERIVATIVES AS AGRICULTURAL CHEMICALS GLOBACHEM NV (BE) 2021-08-05 WO disclosed
EP-3666769-A1 NOVEL CASPASE INHIBITORS RIJKSUNIVERSITEIT GRONINGEN (NL) 2020-06-17 EP disclosed
US-8586617-B2 Aminomethyl-4-imidazoles HOFFMANN-LA ROCHE INC. (US) 2013-11-19 US disclosed
CN-101528710-B Aminomethyl-4-imidazoles HOFFMANN LA ROCHE 2012-11-07 CN disclosed
EP-2076497-B1 AMINOMETHYL-4-IMIDAZOLES HOFFMANN LA ROCHE (CH) 2012-02-22 EP disclosed
EP-2076497-A1 AMINOMETHYL-4-IMIDAZOLES F. Hoffmann-Roche AG (CH) 2009-07-08 EP disclosed
US-20080119535-A1 AMINOMETHYL-4-IMIDAZOLES F. HOFFMANN-LA ROCHE AG (CH) 2008-05-22 US disclosed
WO-2008046757-A1 AMINOMETHYL-4-IMIDAZOLES F. HOFFMANN-LA ROCHE AG (CH) 2008-04-24 WO disclosed
US-4239888-A 1-Phenyluracils PFIZER INC. (US) 1980-12-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080119535-A1 AMINOMETHYL-4-IMIDAZOLES INMT, HTR4, MC4R CYP3A4 22/4885TSHR 2098/4885HPGD 3580/4885
US-20230151023-A1 PYRIDO[2,3-E]OXAZINE DERIVATIVES AS AGRICULTURAL CHEMICALS PNPO, HPD, PDXK CYP3A4 434/4885TSHR 4007/4885HPGD 488/4885
US-12415815-B2 Pyrido[2,3-e]oxazine derivatives as agricultural chemicals PNPO, HPD, PDXK CYP3A4 434/4885TSHR 4007/4885HPGD 488/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.