Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29716454 | 0.89 | KMT2A (0.50) | KMT2AMEN1ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL15549442 | 0.89 | FPR2 (0.53) | KMT2AMEN1ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL8878617 | 0.89 | KMT2A (0.65) | KMT2AMEN1ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL5674705 | 0.89 | PKM (0.53) | KMT2AMEN1PKM | |
| SCHEMBL965515 | 0.89 | LMNA (0.62) | KMT2AMEN1ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL23986656 | 0.88 | ALDH1A1 (0.66) | KMT2AMEN1ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL22309108 | 0.87 | MEN1 (0.68) | KMT2AMEN1ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL16112188 | 0.87 | LMNA (0.55) | KMT2AMEN1ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL2185224 | 0.86 | KDM1A (0.46) | KMT2AMEN1 | |
| SCHEMBL22793051 | 0.86 | ALDH1A1 (0.51) | KMT2AMEN1ALDH1A1LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118359642-A | Spiro aromatic ring compound and application thereof | 上海奕拓医药科技有限责任公司 | 2024-07-19 | — | — | CN | disclosed |
| CN-111566104-B | Spiro aromatic ring compound and application thereof | 上海奕拓医药科技有限责任公司 | 2024-05-17 | — | — | CN | disclosed |
| CN-111592525-B | Spiro aromatic ring compound and application thereof | 上海奕拓医药科技有限责任公司 | 2020-12-08 | — | — | CN | disclosed |
| CN-111592525-A | Spiro aromatic ring compound and application thereof | 上海奕拓医药科技有限责任公司 | 2020-08-28 | — | — | CN | disclosed |
| CN-111566104-A | Spiro aromatic ring compound and application thereof | 上海奕拓医药科技有限责任公司 | 2020-08-21 | — | — | CN | disclosed |
| US-20100152160-A1 | NOVEL BENZODIOXANE AND BENZOXAZINE DERIVATIVES USEFUL AS CC CHEMOKINE RECEPTOR LIGANDS | KHAMRAI UTTAM | 2010-06-17 | — | — | US | disclosed |
| US-20100152160-A1 | NOVEL BENZODIOXANE AND BENZOXAZINE DERIVATIVES USEFUL AS CC CHEMOKINE RECEPTOR LIGANDS | KHAMRAI UTTAM | 2010-06-17 | — | — | US | disclosed |
| WO-2010068881-A1 | NOVEL BENZODIOXANE AND BENZOXAZINE DERIVATIVES USEFUL AS CC CHEMOKINE RECEPTOR LIGANDS | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-06-17 | — | — | WO | disclosed |
| US-20100152160-A1 | NOVEL BENZODIOXANE AND BENZOXAZINE DERIVATIVES USEFUL AS CC CHEMOKINE RECEPTOR LIGANDS | KHAMRAI UTTAM | 2010-06-17 | — | — | US | disclosed |
| US-6020347-A | 4-substituted-4-piperidine carboxamide derivatives | MERCK & CO., INC. (US) | 2000-02-01 | — | — | US | disclosed |
| WO-1999025685-A1 | 4-SUBSTITUTED-4-PIPERIDINE CARBOXAMIDE DERIVATIVES | MERCK & CO., INC. (US) | 1999-05-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152160-A1 | NOVEL BENZODIOXANE AND BENZOXAZINE DERIVATIVES USEFUL AS CC CHEMOKINE RECEPTOR LIGANDS | CCR1, CCR4, CCR5 | KMT2A 3495/4885MEN1 4595/4885ALDH1A1 903/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.