Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
| ▸ | PKM | P14618 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.56 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.56 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.56 |
| ▸ | ALPL | P05186 | 1/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11078628 | 1.00 | SMN1; SMN2 (0.59) | SMN1; SMN2NPC1RAB9APKMMAPT | |
| SCHEMBL27772395 | 0.82 | ALDH1A1 (0.56) | SMN1; SMN2NPC1RAB9APKMMAPT | |
| SCHEMBL28287259 | 0.82 | GRM4 (0.54) | SMN1; SMN2NPC1RAB9APKMMAPT | |
| SCHEMBL11082962 | 0.81 | SMN1; SMN2 (0.60) | SMN1; SMN2NPC1RAB9APKMMAPT | |
| SCHEMBL11082959 | 0.81 | SMN1; SMN2 (0.60) | SMN1; SMN2NPC1RAB9APKMMAPT | |
| SCHEMBL30037891 | 0.79 | ALDH1A1 (0.61) | SMN1; SMN2NPC1RAB9APKMMAPT | |
| SCHEMBL29576494 | 0.79 | KDM4E (0.68) | SMN1; SMN2NPC1RAB9APKMMAPT | |
| SCHEMBL30166417 | 0.79 | KDM4E (0.68) | SMN1; SMN2NPC1RAB9APKMMAPT | |
| SCHEMBL162189 | 0.79 | ALDH1A1 (0.61) | SMN1; SMN2NPC1RAB9APKMMAPT | |
| SCHEMBL109657 | 0.79 | HDAC3 (0.61) | SMN1; SMN2NPC1RAB9AHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111868037-B | Fused cyclic urea derivatives as CRHR2 antagonists | 拉夸里亚创药株式会社 | 2023-10-13 | — | — | CN | claimed |
| JP-57120597-A | — | — | None | — | — | JP | disclosed |
| CN-119585260-A | Heterocyclic compound, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2025-03-07 | — | — | CN | disclosed |
| US-11931348-B2 | Methods of treating elevated plasma cholesterol | Montréal Heart Institute (CA) | 2024-03-19 | — | — | US | disclosed |
| WO-2024041613-A1 | HETEROCYCLIC COMPOUND, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL USE THEREOF | 江苏恒瑞医药股份有限公司 | 2024-02-29 | — | — | WO | disclosed |
| US-20240018115-A1 | ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE | LOXO ONCOLOGY, INC. | 2024-01-18 | — | — | US | disclosed |
| CN-111868037-B | Fused cyclic urea derivatives as CRHR2 antagonists | 拉夸里亚创药株式会社 | 2023-10-13 | — | — | CN | disclosed |
| US-20230088095-A1 | METHODS OF TREATING ELEVATED PLASMA CHOLESTEROL | Montréal Heart Institute (CA) | 2023-03-23 | — | — | US | disclosed |
| CN-109641854-A | Integration stress access regulator | 卡里科生命科学有限责任公司 | 2019-04-16 | — | — | CN | disclosed |
| US-8912342-B2 | Pyrazole synthesis by coupling of carboxylic acid derivatives and enamines | Westfälische Wilhelms Universität Münster (DE) | 2014-12-16 | — | — | US | disclosed |
| EP-2657228-A1 | Pyrazole synthesis by the coupling of carboxylic acid derivatives and enamines | Westfälische Wilhelms-Universität Münster (DE) | 2013-10-30 | — | — | EP | disclosed |
| US-20130204011-A1 | PYRAZOLE SYNTHESIS BY COUPLING OF CARBOXYLIC ACID DERIVATIVES AND ENAMINES | WESTFAELISCHE WILHELMS UNIVERSITAET MUENSTER (DE) | 2013-08-08 | — | — | US | disclosed |
| US-20130102600-A1 | Heteroaryl hydroxamic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease | F. HOFFMANN-LA ROCHE LTD (CH) | 2013-04-25 | — | — | US | disclosed |
| WO-2010077992-A1 | AMINOPYRIDINE AND CARBOXYPYRIDINE COMPOUNDS AS PHOSPHODIESTERASE 10 INHIBITORS | AMGEN INC. (US) | 2010-07-08 | — | — | WO | disclosed |
| WO-2010033906-A2 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-03-25 | — | — | WO | disclosed |
| EP-0065039-B1 | AN O-(N-ALKOXY-PYRIDINECARBOXIMIDOYL)PHOSPHATE, A PROCESS FOR PRODUCING THE SAME, AND AN INSECTICIDAL OR ACARICIDAL COMPOSITION CONTAINING THE SAME | ISHIHARA SANGYO KAISHA LTD. (JP) | 1984-08-22 | — | — | EP | disclosed |
| EP-0065039-A1 | An O-(N-alkoxy-pyridinecarboximidoyl)phosphate, a process for producing the same, and an insecticidal or acaricidal composition containing the same | ISHIHARA SANGYO KAISHA LTD. (JP) | 1982-11-24 | — | — | EP | disclosed |
| JP-S57120597-A | ORGANOPHOSPHORUS COMPOUND AND INSECTICIDE CONTAINING THE SAME | ISHIHARA SANGYO KAISHA LTD | 1982-07-27 | — | — | JP | disclosed |
| US-4327089-A | O-(N-Alkoxy-pyridinecarboximidoyl) phosphates, process for producing the same, and insecticidal or acaridical compositions containing the same | ISHIHARA SANGYO KAISHA LTD. (JP) | 1982-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130204011-A1 | PYRAZOLE SYNTHESIS BY COUPLING OF CARBOXYLIC ACID DERIVATIVES AND ENAMINES | PPOX, PDK2, PNPO | SMN1; SMN2 3647/4885NPC1 3142/4885RAB9A 3942/4885 |
| US-20240018115-A1 | ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE | PIK3CA, PIK3R4, PIK3R5 | SMN1; SMN2 1813/4885NPC1 1577/4885RAB9A 669/4885 |
| US-11931348-B2 | Methods of treating elevated plasma cholesterol | CETP, LDLR, APOB | SMN1; SMN2 3911/4885NPC1 11/4885RAB9A 2649/4885 |
| US-20230088095-A1 | METHODS OF TREATING ELEVATED PLASMA CHOLESTEROL | CETP, LDLR, APOB | SMN1; SMN2 3911/4885NPC1 11/4885RAB9A 2649/4885 |
| US-20130102600-A1 | Heteroaryl hydroxamic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease | FAH, SLC10A1, OAT | SMN1; SMN2 1282/4885NPC1 653/4885RAB9A 3199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.