Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PHGDH | O43175 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.44 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3358211 | 0.90 | MAPT (0.47) | POLBSMN1; SMN2ALOX5ALDH1A1MAPT | |
| SCHEMBL3351542 | 0.89 | ALDH1A1 (0.46) | POLBSMN1; SMN2ALOX5ALDH1A1MAPT | |
| SCHEMBL3353911 | 0.89 | ALDH1A1 (0.45) | POLBL3MBTL1ALDH1A1MAPTLMNA | |
| SCHEMBL2075770 | 0.83 | POLB (0.47) | POLBSMN1; SMN2ALOX5ALDH1A1MAPT | |
| SCHEMBL13537324 | 0.80 | ALOX5 (0.46) | POLBSMN1; SMN2ALOX5KDM4EUSP2 | |
| SCHEMBL1558335 | 0.80 | ALDH1A1 (0.60) | POLBSMN1; SMN2ALOX5KDM4EALDH1A1 | |
| SCHEMBL7508094 | 0.78 | CDK2 (0.46) | POLBL3MBTL1MAPTLMNANPC1 | |
| SCHEMBL5327849 | 0.77 | CDK2 (0.56) | POLBL3MBTL1ALDH1A1MAPTTDP1 | |
| SCHEMBL6488744 | 0.77 | MAPT (0.49) | POLBMAPTLMNANPC1 | |
| SCHEMBL3352674 | 0.76 | CDK2 (0.44) | POLBL3MBTL1ALDH1A1MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2141163-A1 | Substituted thiazolidinones, their production and utilisation as medicine | Bayer Schering Pharma AG (DE) | 2010-01-06 | — | — | EP | disclosed |