Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 2/20 | 0.46 |
| ▸ | SYK | P43405 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 4/20 | 0.41 |
| ▸ | JAK2 | O60674 | 5/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3358248 | 0.91 | ZAP70 (0.44) | ZAP70SYKBRD4BTKJAK2 | |
| SCHEMBL3358764 | 0.85 | SYK (0.42) | ZAP70SYKBRD4BTKJAK2 | |
| SCHEMBL3359180 | 0.81 | MAPT (0.50) | ZAP70SYKBRAFBTKMAPT | |
| SCHEMBL3362709 | 0.80 | SYK (0.45) | ZAP70SYKBRD4BTKMAPT | |
| SCHEMBL3362463 | 0.80 | ZAP70 (0.49) | ZAP70SYKBTKJAK2MEN1 | |
| SCHEMBL3358985 | 0.80 | ZAP70 (0.43) | ZAP70BRD4BRAFBTKJAK2 | |
| SCHEMBL3362714 | 0.79 | ABL1 (0.45) | ZAP70SYKBTKJAK2MAPT | |
| SCHEMBL3361347 | 0.79 | ZAP70 (0.42) | ZAP70SYKBTKMAPTAURKA | |
| SCHEMBL3359805 | 0.79 | ZAP70 (0.42) | ZAP70SYKBTKJAK2MAPT | |
| SCHEMBL3362620 | 0.78 | ZAP70 (0.42) | ZAP70SYKJAK2MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |