SCHEMBL3359664

SCHEMBL3359664

O=C1NCC(CNC(=O)c2ccc(Cl)s2)O1

nearest known ligand 0.57

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ F10 P00742 19/20 0.57
▸ F2 P00734 2/20 0.50
▸ ABCB11 O95342 1/20 0.50
▸ ST14 Q9Y5Y6 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15857721 1.00 F10 (0.57) F10F2ABCB11ST14
SCHEMBL76883 0.80 F10 (0.59) F10F2ABCB11ST14
SCHEMBL946532 0.80 F10 (0.59) F10F2ABCB11ST14
SCHEMBL17588942 0.79 F10 (0.58) F10F2ABCB11ST14
SCHEMBL20618506 0.74 HDAC3 (0.58) F10F2
SCHEMBL8257548 0.73 F10 (0.47) F10F2
SCHEMBL24177659 0.73 F10 (1.00) F10F2ABCB11ST14
SCHEMBL13698655 0.73 F10 (1.00) F10F2ABCB11ST14
SCHEMBL77589 0.73 F10 (1.00) F10F2ABCB11ST14
SCHEMBL8259083 0.73 MAPK1 (0.47) F10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100160301-A1 MICROANGIOPATHY TREATMENT AND PREVENTION BAYER HEALTHCARE AG 2010-06-24 — — US disclosed
US-7592339-B2 Substituted oxazolidinones and their use in the field of blood coagulation BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2009-09-22 — — US disclosed
US-20060258724-A1 Substituted Oxazolidinones and Their Use in the Field of Blood Coagulation BAYER INTELLECTUAL PROPERTY GMBH (DE) 2006-11-16 — — US disclosed
WO-2003000256-A1 SUBSTITUTED OXAZOLIDINONES FOR COMBINATIONAL THERAPY BAYER HEALTHCARE AG (DE) 2003-01-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100160301-A1 MICROANGIOPATHY TREATMENT AND PREVENTION SERPINC1, TFPI, F11 F10 10/4885F2 35/4885ABCB11 3613/4885
US-20060258724-A1 Substituted Oxazolidinones and Their Use in the Field of Blood Coagulation F2, F11, F13B F10 9/4885F2 1/4885ABCB11 337/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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