Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CASP1 | P29466 | 2/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinoline SCHEMBL21535 | 0.90 | ALDH1A1 (0.74) | ALDH1A1KDM4EALOX12MEN1KMT2A | |
| Quinoline SCHEMBL28261411 | 0.90 | ALDH1A1 (0.74) | ALDH1A1KDM4EALOX12MEN1KMT2A | |
| Quinoline SCHEMBL29710686 | 0.90 | ALDH1A1 (0.74) | ALDH1A1KDM4EALOX12MEN1KMT2A | |
| Quinoline SCHEMBL5874241 | 0.90 | ALDH1A1 (0.74) | ALDH1A1KDM4EALOX12MEN1KMT2A | |
| Quinoline SCHEMBL28142303 | 0.90 | ALDH1A1 (0.74) | ALDH1A1KDM4EALOX12MEN1KMT2A | |
| Quinoline SCHEMBL14717992 | 0.89 | ALDH1A1 (0.65) | ALDH1A1KDM4EALOX12MEN1KMT2A | |
| Quinoline SCHEMBL27476711 | 0.89 | ALDH1A1 (0.65) | ALDH1A1KDM4EALOX12MEN1KMT2A | |
| Quinoline SCHEMBL29192334 | 0.88 | ALDH1A1 (0.71) | ALDH1A1KDM4EALOX12MEN1KMT2A | |
| Quinoline SCHEMBL20972298 | 0.88 | ALDH1A1 (0.71) | ALDH1A1KDM4EALOX12MEN1KMT2A | |
| Quinoline SCHEMBL20972296 | 0.88 | ALDH1A1 (0.71) | ALDH1A1KDM4EALOX12MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841744-B1 | 1-PHENYL-3-PIPERAZINE-PYRAZOLES AND PESTICIDAL COMPOSITIONS OF MATTER THEREOF | MERIAL LTD (US) | 2014-09-24 | — | — | EP | disclosed |
| EP-1828140-B1 | 5-AMINOPYRAZOLE DERIVATIVES AS PESTICIDAL COMPOUNDS | MERIAL LTD (US) | 2014-03-05 | — | — | EP | disclosed |
| EP-2069338-B1 | INSECTICIDAL ISOXAZOLINES | BAYER CROPSCIENCE AG (DE) | 2012-11-28 | — | — | EP | disclosed |
| US-8097732-B2 | e.g. 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-(1,3-dithiolan-2-yl)-1H-pyrazole-3-carbonitrile; controlling pests, especially by treatment of domestic animals | MERIAL LIMITED (US) | 2012-01-17 | — | — | US | disclosed |
| EP-1838693-B1 | PYRAZOLE DERIVATIVES AS PESTICIDES | MERIAL LTD (US) | 2011-11-16 | — | — | EP | disclosed |
| US-20110265005-A1 | METHOD, SYSTEM AND APPARATUS FOR MANAGING MESSAGE ATTACHMENTS | RESEARCH IN MOTION LIMITED (CA) | 2011-10-27 | — | — | US | disclosed |
| EP-2332937-A1 | Insecticidal isoxazolines | Bayer CropScience AG (DE) | 2011-06-15 | — | — | EP | disclosed |
| EP-2330106-A1 | Insecticidal isoxazolines | Bayer CropScience AG (DE) | 2011-06-08 | — | — | EP | disclosed |
| US-20110086886-A2 | INSECTICIDAL ISOXAZOLINES | BAYER CROPSCIENCE AG (DE) | 2011-04-14 | — | — | US | disclosed |
| EP-1824845-B1 | 1-ARYLPYRAZOLES AND THEIR USE AS PESTICIDES | MERIAL LTD (US) | 2011-03-09 | — | — | EP | disclosed |
| EP-1838693-A1 | PYRAZOLE DERIVATIVES AS PESTICIDES | Merial Ltd. (US) | 2007-10-03 | — | — | EP | disclosed |
| EP-1828140-A1 | 5-AMINOPYRAZOLE DERIVATIVES AS PESTICIDAL COMPOUNDS | Merial Limited (US) | 2007-09-05 | — | — | EP | disclosed |
| EP-1824845-A1 | 1-ARYLPYRAZOLES AND THEIR USE AS PESTICIDES | Merial Ltd. (US) | 2007-08-29 | — | — | EP | disclosed |
| WO-2006119876-A1 | PESTICIDAL SUBSTITUTED PHENYLETHERS | MERIAL LTD. (GR) | 2006-11-16 | — | — | WO | disclosed |
| WO-2006087162-A1 | PESTICIDAL SUBSTITUTED PIPERIDINES | MERIAL LTD. (US) | 2006-08-24 | — | — | WO | disclosed |
| WO-2006079480-A1 | PESTICIDAL SUBSTITUTED THIOETHERS | MERIAL LTD. (US) | 2006-08-03 | — | — | WO | disclosed |
| WO-2006077070-A1 | CHEMICAL COMPOUNDS, PROCESS FOR THEIR PREPARATION AND USE THEREOF | MERIAL LTD. (US) | 2006-07-27 | — | — | WO | disclosed |
| WO-2006063700-A1 | 1-ARYLPYRAZOLES AND THEIR USE AS PESTICIDES | MERIAL LTD. (US) | 2006-06-22 | — | — | WO | disclosed |
| WO-2006061146-A1 | 5-AMINOPYRAZOLE DERIVATIVES AS PESTICIDAL COMPOUNDS | MERIAL LTD. (US) | 2006-06-15 | — | — | WO | disclosed |
| WO-2006061147-A1 | 1-PHENYL-3-PIPERAZINE-PYRAZOLES AND PESTICIDAL COMPOSITIONS OF MATTER THEREOF | BAYER CROPSCIENCE S. A. (FR) | 2006-06-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110086886-A2 | INSECTICIDAL ISOXAZOLINES | HAX1, INA, CYCS | ALDH1A1 683/4885KDM4E 1969/4885ALOX12 3092/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.