Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 5/20 | 0.40 |
| ▸ | GNAI3 | P08754 | 3/20 | 0.40 |
| ▸ | GNAO1 | P09471 | 3/20 | 0.40 |
| ▸ | GNAI1 | P63096 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17832628 | 0.98 | FAAH (0.42) | FAAHTHRBGNAI3GNAO1GNAI1 | |
| SCHEMBL14566980 | 0.98 | FAAH (0.42) | FAAHTHRBGNAI3GNAO1GNAI1 | |
| SCHEMBL3335249 | 0.98 | FAAH (0.42) | FAAHTHRBGNAI3GNAO1GNAI1 | |
| SCHEMBL10722736 | 0.90 | FAAH (0.48) | FAAHTHRBL3MBTL1CA2GAA | |
| SCHEMBL7122564 | 0.90 | FAAH (0.48) | FAAHTHRBL3MBTL1CA2GAA | |
| SCHEMBL10721831 | 0.90 | FAAH (0.48) | FAAHTHRBL3MBTL1CA2GAA | |
| SCHEMBL28283510 | 0.86 | THRB (0.40) | FAAHTHRBGNAI3GNAO1GNAI1 | |
| SCHEMBL24767441 | 0.82 | FAAH (0.45) | FAAHTHRBL3MBTL1CA2GAA | |
| SCHEMBL10192197 | 0.82 | L3MBTL1 (0.50) | L3MBTL1GAAPKMKDM4EGLA | |
| SCHEMBL7132578 | 0.82 | L3MBTL1 (0.44) | L3MBTL1GAAPKMKDM4EGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100144708-A1 | HETEROCYCLIC COMPOUNDS CONTAINING NITROGEN ATOMS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME FOR TREATMENT OF CANCER | KOREA RESEARCH INSTITITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2010-06-10 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144708-A1 | HETEROCYCLIC COMPOUNDS CONTAINING NITROGEN ATOMS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME FOR TREATMENT OF CANCER | RHOT2, BAX, BCL2 | FAAH 4726/4885THRB 1425/4885GNAI3 413/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.