Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 7/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 2/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3358985 | 0.91 | ZAP70 (0.43) | ZAP70BRAFPLK4FGFR1SRC | |
| SCHEMBL3362463 | 0.86 | ZAP70 (0.49) | ZAP70PLK4MAPTTP53MAPK1 | |
| SCHEMBL3358598 | 0.80 | SYK (0.43) | ZAP70PLK4FGFR1SRCMAPT | |
| SCHEMBL3358312 | 0.79 | MAPT (0.46) | ZAP70PLK4FGFR1SRCMAPT | |
| SCHEMBL3359647 | 0.79 | MAPT (0.43) | ZAP70BRAFMAPTTP53MAPK1 | |
| SCHEMBL3358758 | 0.78 | SYK (0.44) | ZAP70MAPTTP53MAPK1AURKA | |
| SCHEMBL3359805 | 0.78 | ZAP70 (0.42) | ZAP70FGFR1SRCMAPTMAPK1 | |
| SCHEMBL3358947 | 0.78 | CYP2C19 (0.40) | ZAP70MAPTTP53MAPK1AURKA | |
| SCHEMBL3359445 | 0.78 | ZAP70 (0.46) | ZAP70BRAFMAPTAURKAAURKB | |
| SCHEMBL3362709 | 0.78 | SYK (0.45) | ZAP70FGFR1SRCMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |