SCHEMBL336251

SCHEMBL336251

Nc1nc(=O)n([C@H]2C[C@H](O)[C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)cc1CO

nearest known ligand 0.62

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
POLG P54098 2/20 0.54
POLB P06746 3/20 0.54
P2RY2 P41231 2/20 0.53
P2RY4 P51582 2/20 0.53
P2RY6 Q15077 2/20 0.53
DNMT1 P26358 3/20 0.49
DNMT3B Q9UBC3 1/20 0.47
DTYMK P23919 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15810651 1.00 POLG (0.54) POLGPOLBP2RY2P2RY4P2RY6
SCHEMBL20906737 1.00 POLG (0.54) POLGPOLBP2RY2P2RY4P2RY6
SCHEMBL22300298 1.00 POLG (0.54) POLGPOLBP2RY2P2RY4P2RY6
SCHEMBL15201233 1.00 POLG (0.54) POLGPOLBP2RY2P2RY4P2RY6
SCHEMBL2926533 0.98 POLB (0.55) POLGPOLBP2RY2P2RY4P2RY6
SCHEMBL14660974 0.98 POLB (0.55) POLGPOLBP2RY2P2RY4P2RY6
SCHEMBL15472378 0.94 P2RY2 (0.51) POLGPOLBP2RY2P2RY4P2RY6
Triphosphate SCHEMBL28135309 0.91 DNMT1 (0.58) POLGPOLBDNMT1DNMT3B
SCHEMBL1331043 0.90 TYMS (0.55) POLBDNMT1DNMT3B
SCHEMBL336318 0.90 TYMS (0.55) POLBDNMT1DNMT3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 341 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12605397-B2 Deoxy-cytidine or uridine derivatives for use in cancer therapies TETRAGON BIOSCIENCE LTD. (IL) 2026-04-21 US claimed
EP-4591940-A2 DEOXY- CYTIDINE DERIVATIVES FOR USE IN CANCER THERAPIES Hemispherian AS (NO) 2025-07-30 EP claimed
CN-120064427-A Method and analysis system for detecting brain nucleic acid hydrolysate spatial distribution based on mass spectrum imaging 北京脑科学与类脑研究所 2025-05-30 CN claimed
US-20240216415-A1 DEOXY-CYTIDINE OR URIDINE DERIVATIVES FOR USE IN CANCER THERAPIES TETRAGON BIOSCIENCES LTD. (IL) 2024-07-04 US claimed
US-11963973-B2 Deoxy-cytidine or uridine derivatives for use in cancer therapies HEMISPHERIAN AS (NO) 2024-04-23 US claimed
CN-113543789-B Deoxycytidine or uridine derivatives for use in cancer treatment 赫米斯弗连有限公司 2024-04-05 CN claimed
EP-4233879-A1 DEOXY- CYTIDINE DERIVATIVES FOR USE IN CANCER THERAPIES Hemispherian AS (NO) 2023-08-30 EP claimed
EP-3917538-B1 DEOXY- CYTIDINE DERIVATIVES FOR USE IN CANCER THERAPIES HEMISPHERIAN AS (NO) 2023-07-12 EP claimed
US-20220117992-A1 DEOXY-CYTIDINE OR URIDINE DERIVATIVES FOR USE IN CANCER THERAPIES TETRAGON BIOSCIENCES LTD. (IL) 2022-04-21 US claimed
EP-3917538-A1 DEOXY- CYTIDINE OR URIDINE DERIVATIVES FOR USE IN CANCER THERAPIES Hemispherian AS (NO) 2021-12-08 EP claimed
WO-2020157335-A1 DEOXY- CYTIDINE OR URIDINE DERIVATIVES FOR USE IN CANCER THERAPIES HEMISPHERIAN AS (NO) 2020-08-06 WO claimed
CN-104592334-A Method for synthesizing tetrasodium 5-hydroxymethyl and 5-aldehyde-2'-deoxycytidine triphosphate UNIV JIANGXI NORMAL SCI & TECH 2015-05-06 CN claimed
EP-0804446-B1 METHOD AND COMPOSITION FOR STABILIZATION OF LABELLED NUCLEOSIDE TRIPHOSPHATES PHARMACIA BIOTECH INC (US) 2003-07-09 EP claimed
WO-2026102094-A1 COMBINED CHEMISTRY AND COMPUTATIONAL CORRECTIONS FOR METHYL-BIAS FOUNDATION MEDICINE, INC. (US) 2026-05-15 WO disclosed
US-20260125749-A1 HAIRPIN LOOP METHOD FOR DOUBLE STRAND POLYNUCLEOTIDE SEQUENCING USING TRANSMEMBRANE PORES OXFORD NANOPORE TECHNOLOGIES PLC (GB) 2026-05-07 US disclosed
US-12605397-B2 Deoxy-cytidine or uridine derivatives for use in cancer therapies TETRAGON BIOSCIENCE LTD. (IL) 2026-04-21 US disclosed
EP-0286898-A2 Modified labeled nucleotides and polynucleotides and methods of preparing, utilizing and detecting same ENZO BIOCHEM, INC. (US) 1988-10-19 EP disclosed
EP-0285950-A2 A drug delivery conjugate ENZO BIOCHEM, INC. (US) 1988-10-12 EP disclosed
EP-0285058-A2 Modified labeled nucleotides and polynucleotides and methods of preparing, utilizing and detecting same ENZO BIOCHEM, INC. (US) 1988-10-05 EP disclosed
EP-0097373-A2 Modified labeled nucleotides and polynucleotides and methods of preparing, utilizing and detecting same ENZO BIOCHEM, INC. (US) 1984-01-04 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220117992-A1 DEOXY-CYTIDINE OR URIDINE DERIVATIVES FOR USE IN CANCER THERAPIES UMPS, UPP1, TYMP POLG 464/4885POLB 272/4885P2RY2 525/4885
US-11963973-B2 Deoxy-cytidine or uridine derivatives for use in cancer therapies UMPS, UPP1, TYMP POLG 464/4885POLB 272/4885P2RY2 525/4885
US-20240216415-A1 DEOXY-CYTIDINE OR URIDINE DERIVATIVES FOR USE IN CANCER THERAPIES UMPS, UPP1, TYMP POLG 444/4885POLB 261/4885P2RY2 552/4885
US-12605397-B2 Deoxy-cytidine or uridine derivatives for use in cancer therapies CDA, DCTD, RNMT POLG 354/4885POLB 57/4885P2RY2 203/4885
US-20260125749-A1 HAIRPIN LOOP METHOD FOR DOUBLE STRAND POLYNUCLEOTIDE SEQUENCING USING TRANSMEMBRANE PORES POLRMT, PITPNB, NUP205 POLG 528/4885POLB 81/4885P2RY2 1807/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.