Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 4/20 | 0.42 |
| ▸ | JAK3 | P52333 | 3/20 | 0.42 |
| ▸ | SYK | P43405 | 8/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | YES1 | P07947 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3361081 | 0.86 | SYK (0.48) | ZAP70JAK2JAK3SYKAURKB | |
| SCHEMBL3362714 | 0.82 | ABL1 (0.45) | ZAP70JAK2JAK3SYKMAPT | |
| SCHEMBL3358248 | 0.82 | ZAP70 (0.44) | ZAP70JAK2JAK3SYKMAPT | |
| SCHEMBL1047439 | 0.79 | ZAP70 (0.67) | ZAP70JAK2JAK3SYK | |
| SCHEMBL3359805 | 0.79 | ZAP70 (0.42) | ZAP70JAK2SYKMAPTABL1 | |
| SCHEMBL3358947 | 0.79 | CYP2C19 (0.40) | ZAP70JAK2JAK3SYKMAPT | |
| SCHEMBL3362709 | 0.79 | SYK (0.45) | ZAP70SYKMAPTPKMYT1 | |
| SCHEMBL3359445 | 0.78 | ZAP70 (0.46) | ZAP70JAK2JAK3SYKMAPT | |
| SCHEMBL3358764 | 0.78 | SYK (0.42) | ZAP70JAK2SYKMAPTABL1 | |
| SCHEMBL3359607 | 0.78 | KDR (0.41) | ZAP70JAK2JAK3SYKMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |