Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM5 | Q9NZQ8 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5643243 | 0.89 | ALDH1A1 (0.43) | ALDH1A1MAPTHPGDPTGER1MEN1 | |
| SCHEMBL3366543 | 0.74 | TP53 (0.48) | ALDH1A1MAPTPTGER1MEN1KMT2A | |
| SCHEMBL3366546 | 0.72 | TP53 (0.49) | ALDH1A1MAPTPTGER1MEN1KMT2A | |
| SCHEMBL3364021 | 0.71 | MAPT (0.62) | TRPM5ALDH1A1MAPTHPGDPTGER1 | |
| SCHEMBL3364018 | 0.71 | MAPT (0.62) | TRPM5ALDH1A1MAPTHPGDPTGER1 | |
| SCHEMBL3364725 | 0.71 | OXTR (0.52) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL3364719 | 0.71 | OXTR (0.52) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL3399458 | 0.68 | OXTR (0.50) | ALDH1A1MAPTHPGDMEN1KMT2A | |
| SCHEMBL31612237 | 0.65 | AKR1C2 (0.75) | TRPM5ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL27778807 | 0.65 | AKR1C2 (0.75) | TRPM5ALDH1A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1335901-B1 | PHARMACEUTICALLY ACTIVE SULFANILIDE DERIVATIVES | MERCK SERONO SA (CH) | 2010-04-14 | — | — | EP | disclosed |
| US-7312358-B2 | Pharmaceutically active sulfanilide derivatives | LABORATOIRES SERONO SA (CH) | 2007-12-25 | — | — | US | disclosed |