Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT5A | Q9NQR1 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.30 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL652131 | 1.00 | HTT (0.32) | HTTKMT5ADPP4HSD11B1LMNA | |
| SCHEMBL652986 | 1.00 | HTT (0.32) | HTTKMT5ADPP4HSD11B1LMNA | |
| SCHEMBL15946734 | 0.86 | CHRNB2 (0.43) | HTTKMT5ADPP4HSD11B1 | |
| SCHEMBL21707130 | 0.81 | TEAD1 (0.46) | — | |
| SCHEMBL9790975 | 0.77 | KMT5A (0.42) | KMT5A | |
| SCHEMBL21707126 | 0.74 | TEAD1 (0.47) | — | |
| SCHEMBL4798583 | 0.74 | USP30 (0.38) | DPP4HSD11B1USP30 | |
| SCHEMBL4887983 | 0.74 | CHRNB2 (0.36) | DPP4HSD11B1USP30 | |
| SCHEMBL3786744 | 0.72 | CHRNB2 (0.33) | — | |
| SCHEMBL2413966 | 0.72 | HCRTR1 (0.45) | KMT5ADPP4HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1515965-B1 | PHENYLAMINOPYRIMIDINES AND THEIR USE AS RHO-KINASE INHIBITORS | BAYER SCHERING PHARMA AG (DE) | 2010-10-06 | — | — | EP | disclosed |
| EP-1515965-A1 | PHENYLAMINOPYRIMIDINES AND THEIR USE AS RHO-KINASE INHIBITORS | Bayer Aktiengesellschaft (DE) | 2005-03-23 | — | — | EP | disclosed |
| WO-2003106450-A1 | PHENYLAMINOPYRIMIDINES AND THEIR USE AS RHO-KINASE INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2003-12-24 | — | — | WO | disclosed |