Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6314726 | 0.98 | CA1 (0.40) | CA1MAPTCA2GPR84MEN1 | |
| SCHEMBL3249951 | 0.98 | CA1 (0.40) | CA1MAPTCA2GPR84MEN1 | |
| SCHEMBL3241594 | 0.97 | CA1 (0.39) | CA1MAPTCA2GPR84MEN1 | |
| SCHEMBL3366160 | 0.97 | CA1 (0.39) | CA1MAPTCA2GPR84MEN1 | |
| SCHEMBL3245650 | 0.97 | CA1 (0.39) | CA1MAPTCA2GPR84MEN1 | |
| SCHEMBL3365188 | 0.97 | CA1 (0.39) | CA1MAPTCA2GPR84MEN1 | |
| SCHEMBL3367432 | 0.97 | CA1 (0.41) | CA1MAPTCA2GPR84MEN1 | |
| SCHEMBL3246038 | 0.97 | CA1 (0.39) | CA1MAPTCA2GPR84MEN1 | |
| SCHEMBL5706474 | 0.97 | CA1 (0.41) | CA1MAPTCA2GPR84MEN1 | |
| Lithium Ion SCHEMBL3369017 | 0.97 | CA1 (0.39) | CA1MAPTCA2GPR84MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581123-B1 | ANTIMICROBIAL SUTURE COATING | TYCO HEALTHCARE (US) | 2010-02-17 | — | — | EP | claimed |