Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.48 |
| ▸ | S100A4 | P26447 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 3/20 | 0.41 |
| ▸ | CASP1 | P29466 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | TYMS | P04818 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29173988 | 0.86 | ALDH1A1 (0.45) | ALDH1A1HSP90AA1HSP90AB1S100A4CYP2D6 | |
| SCHEMBL29386757 | 0.82 | PDK2 (0.44) | ALDH1A1HSP90AA1HSP90AB1S100A4SMN1; SMN2 | |
| SCHEMBL18383337 | 0.82 | PDK2 (0.44) | ALDH1A1HSP90AA1HSP90AB1S100A4SMN1; SMN2 | |
| SCHEMBL2820392 | 0.80 | ALDH1A1 (0.44) | ALDH1A1HSP90AA1HSP90AB1S100A4CYP2D6 | |
| SCHEMBL13641101 | 0.78 | ALDH1A1 (0.39) | ALDH1A1HSP90AA1HSP90AB1S100A4CYP2D6 | |
| SCHEMBL30349347 | 0.77 | ALDH1A1 (0.41) | ALDH1A1HSP90AA1HSP90AB1S100A4CYP2D6 | |
| SCHEMBL132951 | 0.77 | ALDH1A1 (0.41) | ALDH1A1HSP90AA1HSP90AB1S100A4CYP2D6 | |
| SCHEMBL132952 | 0.77 | ALDH1A1 (0.41) | ALDH1A1HSP90AA1HSP90AB1S100A4CYP2D6 | |
| SCHEMBL12084731 | 0.76 | SIGMAR1 (0.37) | ALDH1A1HSP90AA1HSP90AB1S100A4SMN1; SMN2 | |
| SCHEMBL13144527 | 0.76 | THRB (0.46) | ALDH1A1HSP90AA1HSP90AB1S100A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8013018-B2 | Aminoindane derivative or salt thereof | ASTELLAS PHARMA INC. (JP) | 2011-09-06 | — | — | US | disclosed |
| EP-1478616-B1 | INDANES AND INDANONES AND THEIR USE IN PERFUMERY | GIVAUDAN SA (CH) | 2010-09-22 | — | — | EP | disclosed |
| US-20090186916-A1 | AMINOINDANE DERIVATIVE OR SALT THEREOF | ASTELLAS PHARMA INC. (JP) | 2009-07-23 | — | — | US | disclosed |
| US-7538243-B2 | Indanes and indanones and their use in perfumery | GIVAUDAN SA (CH) | 2009-05-26 | — | — | US | disclosed |
| EP-1697334-A1 | HETEROCYCLIC SUBSTITUTED INDANE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF SCHIZOPHRENIA | Warner-Lambert Company LLC (US) | 2006-09-06 | — | — | EP | disclosed |
| US-20050282819-A1 | Heterocyclic substituted indane derivatives and related compounds for the treatment of schizophrenia | GRAHAM JAMES M | 2005-12-22 | — | — | US | disclosed |
| US-20050148493-A1 | Indanes and indanones and their use in perfumery | FLACHSMANN FELIX (CH) | 2005-07-07 | — | — | US | disclosed |
| WO-2005056540-A1 | HETEROCYCLIC SUBSTITUTED INDANE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF SCHIZOPHRENIA | WARNER-LAMBERT COMPANY LLC (US) | 2005-06-23 | — | — | WO | disclosed |
| EP-1478616-A1 | INDANES AND INDANONES AND THEIR USE IN PERFUMERY | Givaudan SA (CH) | 2004-11-24 | — | — | EP | disclosed |
| WO-2003072533-A1 | INDANES AND INDANONES AND THEIR USE IN PERFUMERY | GIVAUDAN SA (CH) | 2003-09-04 | — | — | WO | disclosed |
| EP-1340741-A1 | Indane derivatives and their use in perfumery | Givaudan SA (CH) | 2003-09-03 | — | — | EP | disclosed |
| EP-0977892-A1 | METHODS AND COMPOSITIONS FOR USE IN MODULATING EXPRESSION OF MATRIX METALLOPROTEINASE GENES | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2000-02-09 | — | — | EP | disclosed |
| WO-1998048055-A1 | METHODS AND COMPOSITIONS FOR USE IN MODULATING EXPRESSION OF MATRIX METALLOPROTEINASE GENES | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1998-10-29 | — | — | WO | disclosed |
| US-4532357-A | Reacting methylindanes with oxygen or air in presence of transition metal oxidation catalyst, recovering product by fractional distillation | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1985-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090186916-A1 | AMINOINDANE DERIVATIVE OR SALT THEREOF | GRIN3A, OPRL1, GRIN2A | ALDH1A1 2681/4885HSP90AA1 3337/4885HSP90AB1 3325/4885 |
| US-20050148493-A1 | Indanes and indanones and their use in perfumery | NISCH, CYP1B1, CYP2E1 | ALDH1A1 195/4885HSP90AA1 3088/4885HSP90AB1 2599/4885 |
| US-20050282819-A1 | Heterocyclic substituted indane derivatives and related compounds for the treatment of schizophrenia | CHRM1, CHRM2, CHRM5 | ALDH1A1 788/4885HSP90AA1 3837/4885HSP90AB1 3490/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.