Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1026968 | 0.74 | CFTR (0.43) | CFTRGOPCALDH1A1KMT2A | |
| SCHEMBL7628236 | 0.74 | CFTR (0.43) | CFTRGOPCALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL3370098 | 0.71 | CFTR (0.40) | CFTRGOPCALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL2403730 | 0.67 | CFTR (0.33) | CFTRGOPC | |
| Hydrochloric Acid SCHEMBL3370512 | 0.67 | CYP11B1 (0.33) | CFTRGOPCALDH1A1NOTUM | |
| SCHEMBL868869 | 0.66 | CFTR (0.68) | CFTRGOPCALDH1A1KMT2ANOTUM | |
| Hydrochloric Acid SCHEMBL2403732 | 0.64 | CFTR (0.34) | CFTRGOPC | |
| Hydrochloric Acid SCHEMBL3373258 | 0.64 | CFTR (0.41) | CFTRGOPCALDH1A1KMT2ANOTUM | |
| SCHEMBL7212942 | 0.60 | ALDH1A1 (0.53) | CFTRGOPCALDH1A1KMT2ANOTUM | |
| SCHEMBL6363384 | 0.59 | CFTR (0.52) | CFTRGOPCALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010055935-A1 | ETHYLENE-α-OLEFIN COPOLYMER AND MOLDED OBJECT THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2010-05-20 | — | — | WO | disclosed |