Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | CFTR | P13569 | 1/20 | 0.31 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27522612 | 0.78 | HPGD (0.38) | CYP11B1CYP11B2ALDH1A1HPGDSIGMAR1 | |
| SCHEMBL7628236 | 0.74 | CFTR (0.43) | CYP11B1CYP11B2ALDH1A1HPGDSIGMAR1 | |
| SCHEMBL1026968 | 0.74 | CFTR (0.43) | CYP11B1CYP11B2ALDH1A1HPGDSIGMAR1 | |
| Hydrochloric Acid SCHEMBL8615798 | 0.71 | HTR2C (0.34) | ALDH1A1SIGMAR1CFTRGOPCHTR2C | |
| Hydrochloric Acid SCHEMBL3370517 | 0.71 | CFTR (0.35) | ALDH1A1SIGMAR1CFTRGOPCHTR2C | |
| Hydrochloric Acid SCHEMBL3370096 | 0.67 | CFTR (0.40) | ALDH1A1CFTRGOPCNOTUM | |
| SCHEMBL27546185 | 0.66 | ALDH1A1 (0.40) | CYP11B1CYP11B2ALDH1A1HPGDSIGMAR1 | |
| SCHEMBL7959486 | 0.66 | NPC1 (0.52) | ALDH1A1HPGDCFTRGOPCNPC1 | |
| SCHEMBL3982745 | 0.61 | ALDH1A1 (0.47) | ALDH1A1SIGMAR1CFTRGOPCHTR2C | |
| SCHEMBL319265 | 0.61 | CYP11B2 (0.65) | CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010055935-A1 | ETHYLENE-α-OLEFIN COPOLYMER AND MOLDED OBJECT THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2010-05-20 | — | — | WO | disclosed |