Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.32 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5609602 | 0.88 | KDM4E (0.44) | PKMKCNH2MAPK1KDM4EALDH1A1 | |
| SCHEMBL3814163 | 0.85 | KDM4E (0.38) | KCNH2HRH3MAPK1KDM4ETDP1 | |
| SCHEMBL3375177 | 0.78 | MMP1 (0.38) | MMP1MMP9MMP13PKMKCNH2 | |
| SCHEMBL22688665 | 0.62 | L3MBTL3 (0.42) | KDM4ETDP1 | |
| SCHEMBL26630547 | 0.60 | L3MBTL3 (0.41) | KDM4ETDP1 | |
| SCHEMBL10641391 | 0.59 | HRH3 (0.40) | MMP1MMP9MMP13KCNH2HRH3 | |
| SCHEMBL23334495 | 0.59 | POLB (0.57) | PKMKCNH2HRH3KDM4EALDH1A1 | |
| SCHEMBL21482489 | 0.59 | POLB (0.57) | PKMKCNH2HRH3KDM4EALDH1A1 | |
| SCHEMBL6032178 | 0.59 | SMN1; SMN2 (0.62) | ALDH1A1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL20096193 | 0.58 | HRH3 (0.46) | KCNH2HRH3POLBSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2162432-A2 | ANTIVIRAL COMPOUNDS | Gilead Sciences, Inc. (US) | 2010-03-17 | — | — | EP | disclosed |
| WO-2009005677-A2 | ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2009-01-08 | — | — | WO | disclosed |