Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 14/20 | 0.50 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3372121 | 0.86 | GPR119 (0.58) | GPR119CHEK2SMN1; SMN2 | |
| SCHEMBL3373764 | 0.85 | CHEK2 (0.52) | GPR119CHEK2SMN1; SMN2PTPN2PTPN1 | |
| SCHEMBL3372317 | 0.84 | GPR119 (0.50) | GPR119CHEK2SMN1; SMN2 | |
| SCHEMBL14242785 | 0.79 | GPR119 (0.44) | GPR119SMN1; SMN2 | |
| SCHEMBL3373458 | 0.77 | GPR119 (0.56) | GPR119CHEK2SMN1; SMN2 | |
| SCHEMBL18318896 | 0.77 | GPR119 (0.54) | GPR119CHEK2PTPN2PTPN1PTPN6 | |
| SCHEMBL3073527 | 0.75 | GPR119 (0.65) | GPR119CHEK2 | |
| SCHEMBL3373467 | 0.74 | GPR119 (0.50) | GPR119SMN1; SMN2 | |
| SCHEMBL1118096 | 0.74 | GPR119 (0.78) | GPR119SMN1; SMN2 | |
| SCHEMBL2774468 | 0.74 | GPR119 (0.71) | GPR119CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010048149-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |
| WO-2010048149-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |