Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | ATF4 | P18848 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2955123 | 0.89 | HPGD (0.50) | ALDH1A1L3MBTL1CYP1A2CYP2C19GAA | |
| Acetic Acid SCHEMBL10534942 | 0.84 | ALOX15 (0.59) | PTGS2MAOAMAOBALDH1A1L3MBTL1 | |
| SCHEMBL11440981 | 0.83 | MAPT (0.60) | PTGS2ALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL11149214 | 0.83 | PTGS2 (0.50) | PTGS2MAOAMAOBALDH1A1L3MBTL1 | |
| SCHEMBL12452166 | 0.81 | PTGS2 (0.50) | PTGS2MAOAMAOBALDH1A1L3MBTL1 | |
| SCHEMBL3913184 | 0.81 | PTGS2 (0.58) | PTGS2MAOAMAOBALDH1A1L3MBTL1 | |
| SCHEMBL40485 | 0.81 | ALOX15 (0.65) | ALDH1A1MEN1KMT2AATF4MAPT | |
| SCHEMBL10858118 | 0.81 | LMNA (0.58) | ALDH1A1L3MBTL1MEN1KMT2AGAA | |
| SCHEMBL30969690 | 0.81 | ALOX15 (0.65) | ALDH1A1MEN1KMT2AATF4MAPT | |
| SCHEMBL11642577 | 0.81 | ATF4 (0.54) | PTGS2ALDH1A1L3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 124 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023250107-A1 | PROCESS FOR PREPARING MODULATORS OF EUKARYOTIC INITIATION FACTOR 2B | DENALI THERAPEUTICS INC. (US) | 2023-12-28 | — | — | WO | disclosed |
| EP-2968347-B1 | MODULATORS OF THE EIF2ALPHA PATHWAY | UNIV CALIFORNIA (US) | 2023-08-02 | — | — | EP | disclosed |
| EP-3481383-B1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF IRRITABLE BOWEL SYNDROME | CELLIX BIO PRIVATE LTD (IN) | 2023-06-14 | — | — | EP | disclosed |
| US-11547704-B2 | Chemical compounds | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2023-01-10 | — | — | US | disclosed |
| EP-3235799-B1 | OXIME COMPOUND AND HERBICIDE | NISSAN CHEMICAL CORP (JP) | 2022-02-23 | — | — | EP | disclosed |
| WO-2021216722-A1 | STEREOSELECTIVE PROCESS OF MANUFACTURE OF PURINE PHOSPHORAMIDATES | Atea Pharmaceuticals, Inc. (US) | 2021-10-28 | — | — | WO | disclosed |
| US-11000033-B2 | Ketone or oxime compound, and herbicide | NISSAN CHEMICAL CORPORATION (JP) | 2021-05-11 | — | — | US | disclosed |
| US-20200297710-A1 | Chemical Compounds | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-09-24 | — | — | US | disclosed |
| WO-2020012339-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-01-16 | — | — | WO | disclosed |
| US-10391076-B2 | Anti-cancer agent comprising aminoacetonitrile compound as active ingredient | PITNEY PHARMACEUTICALS PTY LTD. (AU) | 2019-08-27 | — | — | US | disclosed |
| WO-2004000797-A1 | ALPHA-SULFONYLAMINO-ACETONITRILES | SYNGENTA PARTICIPATIONS AG (CH) | 2003-12-31 | — | — | WO | disclosed |
| US-6239077-B1 | PESTICIDES; APPLYING TO PLANTS | NIHON NOHYAKU CO., LTD. (JP) | 2001-05-29 | — | — | US | disclosed |
| CN-1234177-A | Amino-acetonitrile derivative, pesticides containing same for farm and gardening and use thereof | NIHON NOHYAKU CO LTD (JP) | 1999-11-10 | — | — | CN | disclosed |
| EP-0953565-A2 | Aminoacetonitrile derivative, agricultural and horticultural insecticide containing the same, and use thereof | NIHON NOHYAKU CO., LTD. (JP) | 1999-11-03 | — | — | EP | disclosed |
| EP-0413843-B1 | Dithiolane derivatives | NIHON NOHYAKU CO LTD (JP) | 1994-12-21 | — | — | EP | disclosed |
| US-5041440-A | Treatment and prophylaxis of liver disorders | NIHON NOHYAKU CO., LTD. (JP) | 1991-08-20 | — | — | US | disclosed |
| EP-0114374-B1 | SUBSTITUTED 4-AMINOMETHYLENE CHROMANS OR CHROMENES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICINES | BAYER AG (DE) | 1986-07-23 | — | — | EP | disclosed |
| US-4563458-A | CIRCULATORY SYSTEM DISORDERS | BAYER AKTIENGESELLSCHAFT (DE) | 1986-01-07 | — | — | US | disclosed |
| EP-0114374-A1 | Substituted 4-aminomethylene chromans or chromenes, process for their preparation and their use in medicines | BAYER AG (DE) | 1984-08-01 | — | — | EP | disclosed |
| US-4149006-A | Prostaglandin derivatives having alkynyl, hydroxy and aryloxy junctions in the 2β side chain | G. D. SEARLE & CO. (US) | 1979-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11000033-B2 | Ketone or oxime compound, and herbicide | OR10J3, CYP1B1, CBR3 | PTGS2 2838/4885MAOA 1665/4885MAOB 461/4885 |
| US-20200297710-A1 | Chemical Compounds | ATF4, XBP1, EIF2B5 | PTGS2 1459/4885MAOA 4679/4885MAOB 3828/4885 |
| US-10391076-B2 | Anti-cancer agent comprising aminoacetonitrile compound as active ingredient | RB1, CCNA1, CCNT1 | PTGS2 3380/4885MAOA 3129/4885MAOB 3015/4885 |
| US-11547704-B2 | Chemical compounds | ATF4, XBP1, EIF2B5 | PTGS2 1459/4885MAOA 4679/4885MAOB 3828/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.