Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | PGR | P06401 | 2/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.42 |
| ▸ | AR | P10275 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10528332 | 0.93 | ESR1 (0.50) | NR1H2CA2SLC6A4MAOAESR1 | |
| SCHEMBL3947933 | 0.89 | CA2 (0.41) | NR1H2CA2SLC6A4MAOAESR1 | |
| Hydroquinone SCHEMBL27639375 | 0.88 | ALDH1A1 (0.48) | CA2SLC6A4MAOAESR1CYP3A4 | |
| SCHEMBL346860 | 0.86 | SLC6A4 (0.56) | CA2SLC6A4MAOAALDH1A1MAPK1 | |
| SCHEMBL13766589 | 0.84 | APP (0.57) | CA2SLC6A4LMNACYP3A4MAPT | |
| SCHEMBL3720925 | 0.80 | CA2 (0.52) | NR1H2CA2SLC6A4MAOAESR1 | |
| SCHEMBL10407904 | 0.78 | NR1H2 (0.55) | NR1H2CA2ESR1LMNACYP3A4 | |
| SCHEMBL9793575 | 0.78 | SLC6A4 (0.50) | SLC6A4MAOALMNAPTGS2SMN1; SMN2 | |
| SCHEMBL10316183 | 0.78 | SLC6A4 (0.50) | NR1H2CA2SLC6A4MAOALMNA | |
| SCHEMBL7693661 | 0.78 | NR1H2 (0.55) | NR1H2CA2ESR1LMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 123 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0370219-A1 | 4-Trifluor methyl mercaptophenols and their preparation | BAYER AG (DE) | 1990-05-30 | — | — | EP | claimed |
| US-20250145621-A1 | 1H-PYRROLO[2,3-c]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-c]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS | INCYTE HOLDINGS CORPORATION | 2025-05-08 | — | — | US | disclosed |
| US-12227502-B2 | 1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c] pyridin-7(6H)-ones as inhibitors of BET proteins | INCYTE CORPORATION (US) | 2025-02-18 | — | — | US | disclosed |
| CN-118176179-A | Novel spiro compounds | 田边三菱制药株式会社 | 2024-06-11 | — | — | CN | disclosed |
| US-20240002381-A1 | 1H-PYRROLO[2,3-c]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-c]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS | INCYTE CORPORATION | 2024-01-04 | — | — | US | disclosed |
| CN-113574041-B | Bisphenol production method and polycarbonate resin production method | 三菱化学株式会社 | 2023-10-13 | — | — | CN | disclosed |
| US-11780849-B2 | Imino sulfanone inhibitors of ENPP1 | VOLASTRA THERAPEUTICS, INC. (US) | 2023-10-10 | — | — | US | disclosed |
| US-11780849-B2 | Imino sulfanone inhibitors of ENPP1 | VOLASTRA THERAPEUTICS, INC. (US) | 2023-10-10 | — | — | US | disclosed |
| EP-4218766-A1 | 1H-PYRROLO[2,3-C]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-C]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS | Incyte Holdings Corporation (US) | 2023-08-02 | — | — | EP | disclosed |
| EP-4218766-A1 | 1H-PYRROLO[2,3-C]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-C]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS | Incyte Holdings Corporation (US) | 2023-08-02 | — | — | EP | disclosed |
| US-4275249-A | ALUMINA ALKYLATION CATALYST CONTAINING FLUORIDE OR CHLORIDE CATALYST | UOP INC. (US) | 1981-06-23 | — | — | US | disclosed |
| US-4275248-A | CATALYTIC ALKYLATION OF PHENOL WITH PROPYLENE USING FLUORIDED ALUMINA AS CATALYST | UOP INC. (US) | 1981-06-23 | — | — | US | disclosed |
| US-4260833-A | Preparation of alkylphenols | UOP INC. (US) | 1981-04-07 | — | — | US | disclosed |
| US-4143076-A | MERCAPTO PHENOLIC AND ALKYLTHIO PHENOLIC ANTIOXIDANTS | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1979-03-06 | — | — | US | disclosed |
| US-4128530-A | Mercapto phenolic and alkylthio phenolic antioxidants | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1978-12-05 | — | — | US | disclosed |
| US-4077962-A | WATER INSOLUBLE, GREEN-YELLOW, SYNTHETIC FIBERS | BAYER AKTIENGESELLSCHAFT (DT) | 1978-03-07 | — | — | US | disclosed |
| US-4042705-A | 1-Methyl-2-(phenyl-oxymethyl)-5-nitro-imidazoles and process for their manufacture | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-08-16 | — | — | US | disclosed |
| US-4027018-A | INSECTICIDES, ACARACIDES, NEMATOCIDES | BAYER AKTIENGESELLSCHAFT (DT) | 1977-05-31 | — | — | US | disclosed |
| US-4000270-A | INSECTIDES, ACARICIDES, NEMATOCIDES | BAYER AKTIENGESELLSCHAFT (DT) | 1976-12-28 | — | — | US | disclosed |
| US-3954919-A | INSECTICIDES, MITICIDES, NEMATOCIDES | BAYER AKTIENGESELLSCHAFT (DT) | 1976-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11780849-B2 | Imino sulfanone inhibitors of ENPP1 | ENPP1, ENPP3, SMPD1 | NR1H2 4007/4885CA2 4348/4885SLC6A4 3733/4885 |
| US-20240002381-A1 | 1H-PYRROLO[2,3-c]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-c]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS | BRD3, BRD1, BRD2 | NR1H2 3389/4885CA2 4825/4885SLC6A4 4622/4885 |
| US-20250145621-A1 | 1H-PYRROLO[2,3-c]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-c]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS | BRD3, BRD1, BRD2 | NR1H2 3389/4885CA2 4825/4885SLC6A4 4622/4885 |
| US-12227502-B2 | 1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c] pyridin-7(6H)-ones as inhibitors of BET proteins | BRD3, BRD1, BRD2 | NR1H2 3389/4885CA2 4825/4885SLC6A4 4622/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.