SCHEMBL10316183

SCHEMBL10316183

CCSc1ccc(Sc2ccc(SCC)cc2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 10/20 0.50
MAOA P21397 1/20 0.50
NR1H2 P55055 1/20 0.41
CYP3A4 P08684 1/20 0.41
TSHR P16473 1/20 0.41
MAPK1 P28482 1/20 0.41
GSK3B P49841 1/20 0.40
LMNA P02545 1/20 0.39
HPGD P15428 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
RAB9A P51151 2/20 0.38
NPC1 O15118 1/20 0.38
GAA P10253 1/20 0.35
DDAH1 O94760 1/20 0.35
NOS1 P29475 1/20 0.35
SLC2A1 P11166 1/20 0.34
CA12 O43570 1/20 0.34
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34
CA7 P43166 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL346860 0.91 SLC6A4 (0.56) SLC6A4MAOAMAPK1GSK3BRAB9A
SCHEMBL8591154 0.82 SLC6A4 (0.50) SLC6A4MAOAMAPK1GSK3BHPGD
SCHEMBL9793575 0.82 SLC6A4 (0.50) SLC6A4MAOAGSK3BLMNARAB9A
SCHEMBL169195 0.80 SLC6A4 (0.48) SLC6A4MAOALMNAHPGDRAB9A
SCHEMBL13940796 0.80 SLC6A4 (0.48) SLC6A4MAOA
SCHEMBL22068902 0.78 ALDH1A1 (0.41) SLC6A4MAOARAB9ANPC1
SCHEMBL19454683 0.78 SLC6A4 (0.52) SLC6A4MAOAGSK3BRAB9ANPC1
SCHEMBL4523181 0.78 SLC6A4 (0.52) SLC6A4MAOACYP3A4TSHRMAPK1
SCHEMBL3371540 0.78 NR1H2 (0.50) SLC6A4MAOANR1H2CYP3A4TSHR
SCHEMBL96478 0.78 SLC6A4 (0.47) SLC6A4MAOAMAPK1GSK3BRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230242568-A1 POLYMER LINKED MULTIMERS OF GUANOSINE-3', 5'-CYCLIC MONOPHOSPHATES MIRECA MEDICINES GMBH (DE) 2023-08-03 US disclosed
US-20210317156-A1 NEW POLYMER LINKED MULTIMERS OF GUANOSINE-3', 5'-CYCLIC MONOPHOSPHATES MIRECA MEDICINES GMBH (DE) 2021-10-14 US disclosed
US-8648146-B2 Activated solid support and method GE HEALTHCARE BIO-SCIENCES AB (SE) 2014-02-11 US disclosed
US-8648146-B2 Activated solid support and method GE HEALTHCARE BIO-SCIENCES AB (SE) 2014-02-11 US disclosed
US-20120245301-A1 ACTIVATED SOLID SUPPORT AND METHOD GE HEALTHCARE BIO-SCIENCES AB (SE) 2012-09-27 US disclosed
US-20120245301-A1 ACTIVATED SOLID SUPPORT AND METHOD GE HEALTHCARE BIO-SCIENCES AB (SE) 2012-09-27 US disclosed
US-8217118-B2 Activated solid support and method GE HEALTHCARE BIO-SCIENCES AB (SE) 2012-07-10 US disclosed
US-8217118-B2 Activated solid support and method GE HEALTHCARE BIO-SCIENCES AB (SE) 2012-07-10 US disclosed
US-20090048456-A1 ACTIVATED SOLID SUPPORT AND METHOD GE HEALTHCARE BIO-SCIENCES AB (SE) 2009-02-19 US disclosed
US-20090048456-A1 ACTIVATED SOLID SUPPORT AND METHOD GE HEALTHCARE BIO-SCIENCES AB (SE) 2009-02-19 US disclosed
WO-2007062768-A2 ACTIVATED SOLID SUPPORT AND METHOD GE HEALTHCARE BIO-SCIENCES AB (SE) 2007-06-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230242568-A1 POLYMER LINKED MULTIMERS OF GUANOSINE-3', 5'-CYCLIC MONOPHOSPHATES PRKG1, PRKG2, PRKAG3 SLC6A4 4047/4885MAOA 1533/4885NR1H2 4823/4885
US-20120245301-A1 ACTIVATED SOLID SUPPORT AND METHOD OSTC, HLCS, SPR SLC6A4 2165/4885MAOA 357/4885NR1H2 944/4885
US-20210317156-A1 NEW POLYMER LINKED MULTIMERS OF GUANOSINE-3', 5'-CYCLIC MONOPHOSPHATES PRKG1, PRKG2, PDE7A SLC6A4 4340/4885MAOA 1734/4885NR1H2 4839/4885
US-20090048456-A1 ACTIVATED SOLID SUPPORT AND METHOD OSTC, HLCS, SPR SLC6A4 2165/4885MAOA 357/4885NR1H2 944/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.