Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.49 |
| ▸ | PPARD | Q03181 | 9/20 | 0.44 |
| ▸ | PPARG | P37231 | 6/20 | 0.44 |
| ▸ | PPARA | Q07869 | 6/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 7/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3369091 | 0.93 | ALOX5 (0.51) | ALOX5PSEN1PPARDPPARGPPARA | |
| SCHEMBL3402718 | 0.92 | ALOX5 (0.49) | ALOX5PSEN1PPARDPPARGPPARA | |
| SCHEMBL3370293 | 0.92 | ALOX5 (0.41) | ALOX5PSEN1PPARDPPARGPPARA | |
| SCHEMBL3372499 | 0.88 | PPARG (0.39) | ALOX5PSEN1PPARDPPARGPPARA | |
| SCHEMBL3375391 | 0.86 | ALOX5 (0.42) | ALOX5PSEN1PPARDPPARGPPARA | |
| SCHEMBL3369936 | 0.85 | PPARG (0.46) | ALOX5PSEN1PPARDPPARGPPARA | |
| SCHEMBL3368960 | 0.85 | ALOX5 (0.51) | ALOX5PSEN1PPARDPPARGPPARA | |
| SCHEMBL3372856 | 0.84 | TP53 (0.45) | ALOX5PSEN1PPARGPPARAPOLB | |
| SCHEMBL3369630 | 0.83 | LMNA (0.43) | ALOX5PSEN1PPARDPPARGPPARA | |
| SCHEMBL3374527 | 0.82 | RAB9A (0.44) | PPARDPPARGPPARATP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537091-B1 | NOVEL 2-ARYLTHIAZOLE COMPOUNDS AS PPARALPHA AND PPARGAMMA AGONISTS | HOFFMANN LA ROCHE (CH) | 2010-10-06 | — | — | EP | disclosed |
| US-6809110-B2 | NONINSULIN DEPENDENT DIABETES; SUCH AS 2-ETHOXY-3-(4-(2-(5-METHYL-2-PHENYL-THIAZOL-4-YL)-ETHOXY)-BENZO(B)THIOPHEN-7-YL)-PROPIONIC ACID | HOFFMANN-LA ROCHE INC. | 2004-10-26 | — | — | US | disclosed |
| US-20040110807-A1 | Thiazole derivatives | HOFFMANN-LA ROCHE INC. | 2004-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110807-A1 | Thiazole derivatives | SLC5A1, GPR119, INSR | ALOX5 3343/4885PSEN1 2418/4885PPARD 79/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.