Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | DRD4 | P21917 | 6/20 | 0.36 |
| ▸ | DRD2 | P14416 | 4/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | DRD5 | P21918 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3374256 | 0.72 | CXCR3 (0.42) | KDM4EDRD4DRD2HTR2ALMNA | |
| SCHEMBL3344984 | 0.67 | NPC1 (0.49) | KDM4EDRD4SMN1; SMN2DRD5HTR7 | |
| SCHEMBL13375733 | 0.64 | ALDH1A1 (0.39) | KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL3374752 | 0.63 | DRD2 (0.38) | KDM4EDRD4DRD2LMNAPOLB | |
| SCHEMBL4207045 | 0.63 | MAPT (0.47) | KDM4ELMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL6205484 | 0.63 | TNFRSF1A (0.54) | KDM4ELMNASMN1; SMN2HTTMEN1 | |
| SCHEMBL13374367 | 0.62 | MGAT2 (0.39) | KDM4ESMN1; SMN2 | |
| SCHEMBL2782222 | 0.62 | NPC1 (0.46) | KDM4ESMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL27965042 | 0.61 | MAPT (0.49) | KDM4ELMNASMN1; SMN2HTTMEN1 | |
| SCHEMBL31448683 | 0.61 | CYP2A13 (0.69) | KDM4ELMNAPOLBHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010045006-A1 | METHYLENE AMINES OF THIENO [2,3-D] PYRIMIDINE AND THEIR USE AS ADENOSINE A2A RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2010-04-22 | — | — | WO | disclosed |