Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADH1A | P07327 | 5/20 | 0.42 |
| ▸ | ADH1C | P00326 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ADH4 | P08319 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5253542 | 0.98 | ADH1A (0.44) | ADH1AADH1CCYP1A2HRH4HRH3 | |
| SCHEMBL14159145 | 0.98 | ADH1A (0.44) | ADH1AADH1CCYP1A2HRH4HRH3 | |
| SCHEMBL13891185 | 0.98 | ADH1A (0.39) | ADH1AADH1CCYP1A2HRH4HRH3 | |
| Hydrochloric Acid SCHEMBL27846056 | 0.96 | ADH1A (0.42) | ADH1AADH1CCYP1A2HRH4HRH3 | |
| SCHEMBL14546899 | 0.93 | ADH1A (0.42) | ADH1AADH1CCYP1A2HRH4HRH3 | |
| SCHEMBL24437739 | 0.91 | ADH1A (0.42) | ADH1AADH1CCYP1A2HRH4HRH3 | |
| SCHEMBL15375241 | 0.91 | ADH1A (0.42) | ADH1AADH1CCYP1A2HRH4HRH3 | |
| SCHEMBL17351009 | 0.91 | DNM1 (0.46) | ADH1AADH1CCYP1A2HRH4HRH3 | |
| SCHEMBL24437852 | 0.91 | ADH1A (0.42) | ADH1AADH1CCYP1A2HRH4HRH3 | |
| SCHEMBL24437737 | 0.91 | DNM1 (0.44) | ADH1AADH1CCYP1A2HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9447122-B2 | Arginase inhibitors and methods of use thereof | ASTRAZENECA AB (SE) | 2016-09-20 | — | — | US | disclosed |
| US-8894970-B2 | Arginase inhibitors and methods of use thereof | CORRIDOR PHARMACEUTICALS, INC. (US) | 2014-11-25 | — | — | US | disclosed |
| US-20140227183-A1 | SMALL-MOLECULE HSP90 INHIBITORS | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2014-08-14 | — | — | US | disclosed |
| US-20120171116-A1 | Arginase Inhibitors and Methods of Use Thereof | CORRIDOR PHARMACEUTICALS, INC. | 2012-07-05 | — | — | US | disclosed |
| US-20110104054-A1 | Small-Molecule HSP90 Inhibitors | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2011-05-05 | — | — | US | disclosed |
| US-20100324091-A1 | Pyrazolone Derivative | KOWA COMPANY, LTD. (JP) | 2010-12-23 | — | — | US | disclosed |
| EP-2172458-A1 | PYRAZOLONE DERIVATIVE | Kowa Company, Ltd. (JP) | 2010-04-07 | — | — | EP | disclosed |
| US-20080253965-A1 | Small-Molecule Hsp90 Inhibitors | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2008-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120171116-A1 | Arginase Inhibitors and Methods of Use Thereof | ARG1, ARG2, PRMT1 | ADH1A 948/4885ADH1C 947/4885CYP1A2 493/4885 |
| US-20100324091-A1 | Pyrazolone Derivative | SERPINE1, SERPINC1, TFPI | ADH1A 412/4885ADH1C 511/4885CYP1A2 1008/4885 |
| US-20110104054-A1 | Small-Molecule HSP90 Inhibitors | HSP90AB2P, HSP90AB1, HSP90AA1 | ADH1A 3651/4885ADH1C 3950/4885CYP1A2 826/4885 |
| US-20140227183-A1 | SMALL-MOLECULE HSP90 INHIBITORS | HSP90AB2P, HSP90AB1, HSP90B1 | ADH1A 3680/4885ADH1C 3981/4885CYP1A2 1207/4885 |
| US-20080253965-A1 | Small-Molecule Hsp90 Inhibitors | HSP90AB2P, HSP90AB1, HSP90AA1 | ADH1A 3751/4885ADH1C 3971/4885CYP1A2 1111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.