Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.45 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | MASP2 | O00187 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29131268 | 0.91 | RAB9A (0.45) | LMNACYP1A2CYP3A4MAOAMEN1 | |
| SCHEMBL29122221 | 0.91 | LMNA (0.41) | LMNACYP1A2CYP3A4MAOAMEN1 | |
| SCHEMBL30694356 | 0.87 | KDM4E (0.50) | CYP3A4MEN1KMT2AMAPTKDM4E | |
| SCHEMBL11365527 | 0.82 | MAPT (0.56) | LMNACYP1A2CYP3A4MAOAMEN1 | |
| SCHEMBL7343185 | 0.81 | TDP1 (0.65) | LMNACYP1A2CYP3A4MAOAMEN1 | |
| SCHEMBL9547546 | 0.80 | LMNA (0.47) | LMNACYP1A2CYP3A4MAOAMEN1 | |
| SCHEMBL3181886 | 0.80 | LMNA (0.47) | LMNACYP1A2CYP3A4MAOAMEN1 | |
| SCHEMBL3376212 | 0.80 | PARP10 (0.50) | CYP3A4KMT2AMAPTPOLBTDP1 | |
| SCHEMBL221282 | 0.78 | MAPT (0.57) | LMNACYP1A2CYP3A4MAOAMEN1 | |
| SCHEMBL2151966 | 0.78 | GSK3B (0.64) | LMNACYP1A2CYP3A4MAOAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109169659-B | Application of 4-amino-2-hydroxyacetophenone in preparation of pesticide for resisting agrobacterium infection | 南京理工大学 | 2020-12-04 | — | — | CN | claimed |
| CN-104311567-B | One prepares the method for 4-amino-3-(4-amino-benzene) furo [2,3-d] pyrimidine | SHANGHAI INSTITUTE OF TECHNOLOGY (CN) | 2016-04-27 | — | — | CN | claimed |
| EP-2507243-B1 | SPIROINDOLINONE PYRROLIDINES | HOFFMANN LA ROCHE (CH) | 2015-06-10 | — | — | EP | claimed |
| CN-104311567-A | Method for preparing 4-amino-3-(4-aminobenzene)furo[2,3-d] pyrimidine | SHANGHAI INST TECHNOLOGY | 2015-01-28 | — | — | CN | claimed |
| US-8354444-B2 | Substituted pyrrolidine-2-carboxamides | HOFFMANN-LA ROCHE INC. (US) | 2013-01-15 | — | — | US | claimed |
| EP-2507243-A1 | SPIROINDOLINONE PYRROLIDINES | F. Hoffmann-La Roche AG (CH) | 2012-10-10 | — | — | EP | claimed |
| US-20100152190-A1 | Substituted Pyrrolidine-2-Carboxamides | F. HOFFMANN-LA ROCHE AG (CH) | 2010-06-17 | — | — | US | claimed |
| US-20100075948-A1 | Substituted Pyrrolidine-2-Carboxamides | DING QINGJIE | 2010-03-25 | — | — | US | claimed |
| EP-0011490-B2 | ANALGESIC TABLET AND PROCESS FOR ITS PREPARATION | BEECHAM GROUP PLC (GB) | 1989-10-18 | — | — | EP | claimed |
| EP-0011490-B1 | ANALGESIC TABLET AND PROCESS FOR ITS PREPARATION | BEECHAM GROUP PLC (GB) | 1982-11-03 | — | — | EP | claimed |
| US-11332389-B1 | Recylable multifunctional composites for metal ion removal from water | KING ABDULAZIZ UNIVERSITY (SA) | 2022-05-17 | — | — | US | disclosed |
| CN-109169659-B | Application of 4-amino-2-hydroxyacetophenone in preparation of pesticide for resisting agrobacterium infection | 南京理工大学 | 2020-12-04 | — | — | CN | disclosed |
| CN-109169659-B | Application of 4-amino-2-hydroxyacetophenone in preparation of pesticide for resisting agrobacterium infection | 南京理工大学 | 2020-12-04 | — | — | CN | disclosed |
| CN-109169659-B | Application of 4-amino-2-hydroxyacetophenone in preparation of pesticide for resisting agrobacterium infection | 南京理工大学 | 2020-12-04 | — | — | CN | disclosed |
| EP-2534132-B1 | SUBSTITUTED PYRROLIDINE-2-CARBOXAMIDES | HOFFMANN LA ROCHE (CH) | 2017-04-26 | — | — | EP | disclosed |
| US-4479007-A | Chroman-4-ones and process for preparing same | BAYER AKTIENGESELLSCHAFT (DE) | 1984-10-23 | — | — | US | disclosed |
| US-4415741-A | REACTING O-HYDROXYACETOPHENONE AND CYCLOPENTANONE | BAYER AKTIENGESELLSCHAFT (DE) | 1983-11-15 | — | — | US | disclosed |
| EP-0013879-B1 | REACTIVE DYESTUFFS, THEIR PREPARATION AND THEIR USE FOR DYEING MATERIALS CONTAINING HYDROXYL OR AMIDE GROUPS | BAYER AG (DE) | 1982-09-15 | — | — | EP | disclosed |
| EP-0013879-A1 | Reactive dyestuffs, their preparation and their use for dyeing materials containing hydroxyl or amide groups | BAYER AG (DE) | 1980-08-06 | — | — | EP | disclosed |
| US-4052212-A | ETHER-ESTER | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JA) | 1977-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152190-A1 | Substituted Pyrrolidine-2-Carboxamides | ARG2, CCNY, PYCR1 | LMNA 3002/4885CYP1A2 730/4885CYP3A4 740/4885 |
| US-20100075948-A1 | Substituted Pyrrolidine-2-Carboxamides | ARG2, CCNY, PYCR1 | LMNA 3002/4885CYP1A2 730/4885CYP3A4 740/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.