SCHEMBL337396

SCHEMBL337396

O=C1NCCN2CCCC12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 1.00
KDM4E B2RXH2 4/20 1.00
L3MBTL1 Q9Y468 2/20 0.38
CHRNA7 P36544 1/20 0.34
KMT2A Q03164 2/20 0.34
MAPT P10636 2/20 0.34
GAA P10253 1/20 0.34
MEN1 O00255 1/20 0.34
APEX1 P27695 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
POLB P06746 1/20 0.33
PKM P14618 1/20 0.33
TSHR P16473 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL337149 1.00 ALDH1A1 (1.00) ALDH1A1KDM4EL3MBTL1CHRNA7KMT2A
SCHEMBL2115680 0.94 ALDH1A1 (0.89) ALDH1A1KDM4EL3MBTL1KMT2AMEN1
SCHEMBL25687896 0.92 ALDH1A1 (0.85) ALDH1A1KDM4EL3MBTL1KMT2AMAPT
SCHEMBL25598757 0.92 ALDH1A1 (0.85) ALDH1A1KDM4EL3MBTL1KMT2AMAPT
SCHEMBL337373 0.92 ALDH1A1 (0.85) ALDH1A1KDM4EL3MBTL1CHRNA7KMT2A
SCHEMBL7383705 0.86 ALDH1A1 (0.75) ALDH1A1KDM4EL3MBTL1GAATDP1
SCHEMBL11329761 0.84 ALDH1A1 (0.72) ALDH1A1KDM4EL3MBTL1MAPTGAA
SCHEMBL24221675 0.84 KDM4E (0.71) ALDH1A1KDM4EPOLB
SCHEMBL2301305 0.83 ALDH1A1 (0.71) ALDH1A1KDM4EL3MBTL1KMT2AMAPT
SCHEMBL460242 0.81

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 190 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024138018-A1 TREATMENT OF GEMIN5-MEDIATED DISORDERS UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2024-06-27 WO claimed
US-20230331725-A1 COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE PTC THERAPEUTICS, INC. 2023-10-19 US claimed
EP-4151627-A1 COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE PTC Therapeutics, Inc. (US) 2023-03-22 EP claimed
US-20220251098-A1 COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE PTC THERAPEUTICS, INC. 2022-08-11 US claimed
US-11382918-B2 Methods for treating Huntington's Disease PTC THERAPEUTICS, INC. (US) 2022-07-12 US claimed
US-20210024525-A1 COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE PTC THERAPEUTICS, INC. 2021-01-28 US claimed
US-20210009590-A1 COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE PTC THERAPEUTICS, INC. 2021-01-14 US claimed
US-10851101-B2 Compounds for treating spinal muscular atrophy PTC THERAPEUTICS, INC. (US) 2020-12-01 US claimed
US-20200163973-A1 METHODS FOR TREATING HUNTINGTON'S DISEASE PTC THERAPEUTICS, INC. 2020-05-28 US claimed
US-20200165256-A1 COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE PTC THERAPEUTICS, INC. 2020-05-28 US claimed
WO-2019005980-A1 METHODS FOR TREATING HUNTINGTON'S DISEASE PTC THERAPEUTICS, INC. (US) 2019-01-03 WO claimed
WO-2019005993-A1 METHODS FOR TREATING HUNTINGTON'S DISEASE PTC THERAPEUTICS, INC. (US) 2019-01-03 WO claimed
WO-2018226622-A1 COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE PTC THERAPEUTICS, INC. (US) 2018-12-13 WO claimed
EP-3406252-A1 COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY PTC Therapeutics, Inc. (US) 2018-11-28 EP claimed
EP-2812004-B1 COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY PTC THERAPEUTICS INC (US) 2018-06-27 EP claimed
US-20180105526-A1 COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY PTC THERAPEUTICS INC (US) 2018-04-19 US claimed
US-9914722-B2 Compounds for treating spinal muscular atrophy PTC THERAPEUTICS, INC. (US) 2018-03-13 US claimed
US-9879007-B2 Compounds for treating spinal muscular atrophy PTC THERAPEUTICS, INC. (US) 2018-01-30 US claimed
US-20170129885-A1 COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY HOFFMANN-LA ROCHE INC. 2017-05-11 US claimed
US-9586955-B2 Compounds for treating spinal muscular atrophy PTC THERAPEUTICS, INC. (US) 2017-03-07 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210009590-A1 COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE HTT, HYPK, FH ALDH1A1 1477/4885KDM4E 3163/4885L3MBTL1 3995/4885
US-20210024525-A1 COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE HTT, HYPK, HDAC6 ALDH1A1 1492/4885KDM4E 3404/4885L3MBTL1 4134/4885
US-20180105526-A1 COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY SMN1; SMN2, CPT1B, GYS1 ALDH1A1 1461/4885KDM4E 1926/4885L3MBTL1 1215/4885
US-20220251098-A1 COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE HTT, HYPK, FH ALDH1A1 1524/4885KDM4E 3237/4885L3MBTL1 3944/4885
US-20230331725-A1 COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE HTT, HYPK, HDAC6 ALDH1A1 1492/4885KDM4E 3404/4885L3MBTL1 4134/4885
US-20200163973-A1 METHODS FOR TREATING HUNTINGTON'S DISEASE HTT, HYPK, PARK7 ALDH1A1 2514/4885KDM4E 3963/4885L3MBTL1 2919/4885
US-20200165256-A1 COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE HTT, HYPK, FH ALDH1A1 1524/4885KDM4E 3237/4885L3MBTL1 3944/4885
US-20170129885-A1 COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY SMN1; SMN2, CPT1B, GYS1 ALDH1A1 1461/4885KDM4E 1926/4885L3MBTL1 1215/4885
US-10851101-B2 Compounds for treating spinal muscular atrophy SMN1; SMN2, CPT1B, GYS1 ALDH1A1 1088/4885KDM4E 2384/4885L3MBTL1 1646/4885
US-11382918-B2 Methods for treating Huntington's Disease HTT, HYPK, PARK7 ALDH1A1 2514/4885KDM4E 3963/4885L3MBTL1 2919/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.