Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9251140 | 0.86 | ITGB2 (0.48) | GRM1GRM5CYP3A4 | |
| SCHEMBL21853236 | 0.81 | SMN1; SMN2 (0.56) | ALDH1A1KDM4EHSD17B10L3MBTL1CYP3A4 | |
| SCHEMBL21853250 | 0.81 | SMN1; SMN2 (0.56) | ALDH1A1KDM4EHSD17B10L3MBTL1CYP3A4 | |
| SCHEMBL16238706 | 0.80 | SMN1; SMN2 (0.52) | CDK5CDK5R1GRM1ALDH1A1KDM4E | |
| SCHEMBL9432301 | 0.79 | NOTUM (0.42) | ALDH1A1GRM5SMN1; SMN2 | |
| SCHEMBL3104046 | 0.77 | L3MBTL1 (0.45) | GRM1ALDH1A1GRM5THRBNPSR1 | |
| SCHEMBL29464840 | 0.75 | PLD1 (0.49) | GRM1ALDH1A1KDM4EHSD17B10L3MBTL1 | |
| SCHEMBL3311156 | 0.74 | ALDH1A1 (0.45) | ALDH1A1HSD17B10L3MBTL1SMN1; SMN2 | |
| SCHEMBL21552511 | 0.73 | RIPK1 (0.52) | GRM1ALDH1A1THRBNPSR1KDM4E | |
| SCHEMBL10353108 | 0.71 | ELANE (0.49) | GRM1ALDH1A1KDM4EHSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100022546-A1 | ADAMANTYL DIAMIDE DERIVATIVES AND USES OF SAME | H. LUNDBECK A/S (DK) | 2010-01-28 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022546-A1 | ADAMANTYL DIAMIDE DERIVATIVES AND USES OF SAME | QDPR, ADM2, PDE3B | CDK5 3709/4885DYRK1A 529/4885CDK5R1 2267/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.