Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29200964 | 0.81 | GRM1 (0.41) | MEN1HTTKMT2AKDM4EPOLB | |
| SCHEMBL3100082 | 0.81 | L3MBTL1 (0.44) | L3MBTL1KDM4ECYP2C19RIPK1GRM1 | |
| SCHEMBL27712657 | 0.81 | NOTUM (0.50) | L3MBTL1KDM4ECYP2C19POLBALDH1A1 | |
| SCHEMBL21552511 | 0.81 | RIPK1 (0.52) | L3MBTL1MEN1HTTKMT2AKDM4E | |
| SCHEMBL10353108 | 0.80 | ELANE (0.49) | MEN1HTTKMT2AKDM4EGRM1 | |
| SCHEMBL31028552 | 0.80 | ELANE (0.49) | MEN1HTTKMT2AKDM4EGRM1 | |
| Hydrochloric Acid SCHEMBL29659031 | 0.79 | ELANE (0.48) | MEN1HTTKMT2AKDM4EGRM1 | |
| SCHEMBL3110158 | 0.79 | L3MBTL1 (0.44) | L3MBTL1KDM4ECYP2C19RIPK1GRM1 | |
| SCHEMBL3375465 | 0.77 | CDK5 (0.43) | L3MBTL1KDM4EGRM1ALDH1A1GRM5 | |
| SCHEMBL3904460 | 0.76 | HRH3 (0.39) | MEN1HTTKMT2AGRM1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324250-B2 | Piperidine derivatives as NK3 receptor antagonists | HOFFMANN-LA ROCHE INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-20100256126-A1 | PIPERIDINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | HOFFMANN-LA ROCHE, INC. | 2010-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256126-A1 | PIPERIDINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | HTR3A, OPRL1, OPRK1 | L3MBTL1 4603/4885MEN1 4869/4885HTT 901/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.