Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.57 |
| ▸ | NPC1 | O15118 | 8/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.56 |
| ▸ | RELA | Q04206 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6483534 | 0.85 | RAB9A (0.64) | RAB9ANPC1SMN1; SMN2HPGDNFKB1 | |
| SCHEMBL9693793 | 0.84 | TP53 (0.60) | RAB9ANPC1SMN1; SMN2POLBHPGD | |
| SCHEMBL10869688 | 0.81 | RAB9A (0.56) | RAB9ANPC1SMN1; SMN2POLBHPGD | |
| SCHEMBL9678752 | 0.80 | RAB9A (0.61) | RAB9ANPC1SMN1; SMN2HPGDNFKB1 | |
| SCHEMBL9678412 | 0.76 | RAB9A (0.56) | RAB9ANPC1SMN1; SMN2HPGDNFKB1 | |
| SCHEMBL9675826 | 0.76 | NPC1 (0.53) | RAB9ANPC1SMN1; SMN2POLBHPGD | |
| Leminoprazole SCHEMBL29895760 | 0.74 | ATP4A (0.39) | RAB9ANPC1SMN1; SMN2POLBALDH1A1 | |
| Leminoprazole SCHEMBL143740 | 0.74 | ATP4A (0.39) | RAB9ANPC1SMN1; SMN2POLBALDH1A1 | |
| Leminoprazole SCHEMBL143739 | 0.74 | ATP4A (0.39) | RAB9ANPC1SMN1; SMN2POLBALDH1A1 | |
| Leminoprazole SCHEMBL19086179 | 0.74 | ATP4A (0.38) | RAB9ANPC1SMN1; SMN2POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000027841-A1 | METHOD OF PREPARING SULFIDE DERIVATIVES | DONG-A PHARMACEUTICAL CO., LTD. (KR) | 2000-05-18 | — | — | WO | claimed |
| US-9631181-B2 | Synthesis of prazole compounds | CODEXIS, INC. (US) | 2017-04-25 | — | — | US | disclosed |
| US-20160319252-A1 | SYNTHESIS OF PRAZOLE COMPOUNDS | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2016-11-03 | — | — | US | disclosed |
| US-9422534-B2 | Synthesis of prazole compounds | CODEXIS, INC. (US) | 2016-08-23 | — | — | US | disclosed |
| US-20160076008-A1 | SYNTHESIS OF PRAZOLE COMPOUNDS | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2016-03-17 | — | — | US | disclosed |
| WO-2011071982-A2 | SYNTHESIS OF PRAZOLE COMPOUNDS | CODEXIS, INC. (US) | 2011-06-16 | — | — | WO | disclosed |
| EP-2275139-A1 | Oral pharmaceutical dosage forms comprising a proton pump inhibitor and a NSAID | AstraZeneca AB (SE) | 2011-01-19 | — | — | EP | disclosed |
| EP-0773940-B2 | PROCESS FOR SYNTHESIS OF SUBSTITUTED SULPHOXIDES | ASTRAZENECA AB (SE) | 2010-11-17 | — | — | EP | disclosed |
| EP-1427392-B1 | NEW SELF EMULSIFYING DRUG DELIVERY SYSTEM | NICOX SA (FR) | 2008-02-20 | — | — | EP | disclosed |
| EP-0773940-B1 | PROCESS FOR SYNTHESIS OF SUBSTITUTED SULPHOXIDES | ASTRAZENECA AB (SE) | 2003-06-04 | — | — | EP | disclosed |
| WO-2000027841-A1 | METHOD OF PREPARING SULFIDE DERIVATIVES | DONG-A PHARMACEUTICAL CO., LTD. (KR) | 2000-05-18 | — | — | WO | disclosed |
| US-5948789-A | ASYMMETRIC OXIDATION OF A PRO-CHIRAL SULPHIDE TO THE SINGLE ENANTIOMERS OR AN ENANTIOMERICALLY ENRICHED FORM OF THE CORRESPONDING SULPHOXIDE. OPTICALLY PURE SUBSTITUTED 2-(2-PYRIDINYLMETHYL-SULPHINYL)-1H-BENZIMIDAZOLES. | ASTRA AKTIEBOLAG (SE) | 1999-09-07 | — | — | US | disclosed |
| EP-0773940-A1 | PROCESS FOR SYNTHESIS OF SUBSTITUTED SULPHOXIDES | Astra Aktiebolag (SE) | 1997-05-21 | — | — | EP | disclosed |
| WO-1996002535-A1 | PROCESS FOR SYNTHESIS OF SUBSTITUTED SULPHOXIDES | ASTRA AKTIEBOLAG (SE) | 1996-02-01 | — | — | WO | disclosed |