Sugi Predict

Sugi Predict / Compounds / SCHEMBL3378768

SCHEMBL3378768

SCHEMBL3378768

C/C=C(/C(=O)O)N1CCCC1=O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 2/20 0.50
▸ KMT2A Q03164 3/20 0.41
▸ MAPT P10636 2/20 0.41
▸ BLM P54132 2/20 0.41
▸ KDM4E B2RXH2 1/20 0.41
▸ MEN1 O00255 1/20 0.41
▸ CYP1A2 P05177 1/20 0.41
▸ CYP2D6 P10635 1/20 0.41
▸ THRB P10828 1/20 0.41
▸ CYP2C9 P11712 1/20 0.41
▸ CYP2C19 P33261 1/20 0.41
▸ RECQL P46063 1/20 0.41
▸ BRD4 O60885 1/20 0.39
▸ BRD2 P25440 1/20 0.39
▸ INMT O95050 1/20 0.37
▸ SMN1; SMN2 Q16637 2/20 0.36
▸ MITF O75030 1/20 0.36
▸ ALDH1A1 P00352 2/20 0.36
▸ TSHR P16473 1/20 0.35
▸ CA12 O43570 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3378771 1.00 LMNA (0.50) LMNAKMT2AMAPTBLMKDM4E
SCHEMBL3378778 1.00 LMNA (0.50) LMNAKMT2AMAPTBLMKDM4E
SCHEMBL13430349 0.88 ITGB1 (0.37) LMNAKMT2AMAPTBLMKDM4E
SCHEMBL13788511 0.85 LMNA (0.50) LMNAKMT2AMAPTBLMKDM4E
SCHEMBL1881639 0.83 LMNA (0.48) LMNAKMT2AMAPTBLMKDM4E
SCHEMBL1737652 0.83 LMNA (0.48) LMNAKMT2AMAPTBLMKDM4E
SCHEMBL1737650 0.83 LMNA (0.48) LMNAKMT2AMAPTBLMKDM4E
SCHEMBL1881643 0.83 LMNA (0.48) LMNAKMT2AMAPTBLMKDM4E
SCHEMBL28129585 0.83 LMNA (0.48) LMNAKMT2AMAPTBLMKDM4E
SCHEMBL1881641 0.83 LMNA (0.48) LMNAKMT2AMAPTBLMKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7504353-B2 Hydrogenation catalysts UCB PHARMA, S.A. (BG) 2009-03-17 — — US claimed
EP-1477478-B1 2-oxo-1-pyrrolidine derivatives, process for preparing them and their uses. UCB FARCHIM S A AG LTD (CH) 2010-11-17 — — EP disclosed
EP-1477478-B1 2-oxo-1-pyrrolidine derivatives, process for preparing them and their uses. UCB FARCHIM S A AG LTD (CH) 2010-11-17 — — EP disclosed
US-7504353-B2 Hydrogenation catalysts UCB PHARMA, S.A. (BG) 2009-03-17 — — US disclosed
US-7217826-B2 2-oxo-1-pyrrolidine derivatives, process for preparing them and their uses UCB FARCHIM S.A. (CH) 2007-05-15 — — US disclosed
US-7217826-B2 2-oxo-1-pyrrolidine derivatives, process for preparing them and their uses UCB FARCHIM S.A. (CH) 2007-05-15 — — US disclosed
US-7217826-B2 2-oxo-1-pyrrolidine derivatives, process for preparing them and their uses UCB FARCHIM S.A. (CH) 2007-05-15 — — US disclosed
EP-1604979-A1 2-oxo-1-pyrrolidine derivative and its pharmaceutical uses UCB Farchim S.A. (CH) 2005-12-14 — — EP disclosed
US-6969770-B2 2-oxo-1-pyrrolidine derivatives, process for preparing them and their uses U.C.B. FARCHIM S.A. (CH) 2005-11-29 — — US disclosed
EP-1577295-A1 Process for preparing 2-oxo-1-pyrrolidine derivatives as intermediates UCB Farchim S.A. (CH) 2005-09-21 — — EP disclosed
US-20050159475-A1 2-oxo-1-pyrrolidine derivatives, process for preparing them and their uses SURTEES JOHN (BE) 2005-07-21 — — US disclosed
US-6858740-B2 2-oxo-1-pyrrolidine derivatives, process for preparing them and their uses UCB FARCHIM S.A. (CH) 2005-02-22 — — US disclosed
EP-1477478-A2 2-oxo-1-pyrrolidine derivatives, process for preparing them and their uses. UCB Farchim S.A. (AG - LTD) (CH) 2004-11-17 — — EP disclosed
EP-1263727-B1 2-OXO-1-PYRROLIDINE DERIVATIVES, PROCESS FOR PREPARING THEM AND THEIR USES UCB FARCHIM S A AG LTD (CH) 2004-11-17 — — EP disclosed
US-20040192757-A1 2-oxo-1-pyrrolidine derivatives, process for preparing them and their uses SURTEES JOHN (BE) 2004-09-30 — — US disclosed
US-20040092576-A1 2-OXO-1-PYRROLIDINE DERIVATIVES, PROCESS FOR PREPARING THEM AND THEIR USES SURTEES JOHN (BE) 2004-05-13 — — US disclosed
US-6713635-B2 AS CHEMICAL INTERMEDIATES USED FOR THE PREPARATION OF S-ALPHA-ETHYL-2-OXO-1-PYRROLIDINE ACETAMIDE UCB FARCHIM S.A. (CH) 2004-03-30 — — US disclosed
US-20030040631-A1 2-oxo-1-pyrrolidine derivatives, process for preparing them and their uses UCB FARCHIM S.A. (CH) 2003-02-27 — — US disclosed
EP-1263727-A1 2-OXO-1-PYRROLIDINE DERIVATIVES, PROCESS FOR PREPARING THEM AND THEIR USES UCB Farchim S.A. (AG - LTD) (CH) 2002-12-11 — — EP disclosed
WO-2001064637-A1 2-OXO-1-PYRROLIDINE DERIVATIVES, PROCESS FOR PREPARING THEM AND THEIR USES UCB FARCHIM S.A. (AG - LTD) (CH) 2001-09-07 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040192757-A1 2-oxo-1-pyrrolidine derivatives, process for preparing them and their uses ALDH18A1, PYCR1, PPOX LMNA 2834/4885KMT2A 1816/4885MAPT 3815/4885
US-20040092576-A1 2-OXO-1-PYRROLIDINE DERIVATIVES, PROCESS FOR PREPARING THEM AND THEIR USES ALDH18A1, PYCR1, PPOX LMNA 2834/4885KMT2A 1816/4885MAPT 3815/4885
US-20030040631-A1 2-oxo-1-pyrrolidine derivatives, process for preparing them and their uses ALDH18A1, PYCR1, PPOX LMNA 2834/4885KMT2A 1816/4885MAPT 3815/4885
US-20050159475-A1 2-oxo-1-pyrrolidine derivatives, process for preparing them and their uses ALDH18A1, PYCR1, PPOX LMNA 2314/4885KMT2A 1929/4885MAPT 3823/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.