Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL8193458 | 0.95 | BCAT2 (0.44) | IRAK4HTTBCAT2TSHRALDH1A1 | |
| Sulfamate SCHEMBL8190960 | 0.92 | TSHR (0.42) | IRAK4HTTBCAT2TSHRALDH1A1 | |
| SCHEMBL8526511 | 0.85 | TSHR (0.55) | IRAK4HTTBCAT2TSHRALDH1A1 | |
| SCHEMBL1380696 | 0.85 | TSHR (0.55) | IRAK4HTTBCAT2TSHRALDH1A1 | |
| SCHEMBL6858554 | 0.85 | TSHR (0.44) | TSHRALDH1A1MAPTACE2MEN1 | |
| SCHEMBL3974925 | 0.84 | IRAK4 (0.46) | IRAK4HTTBCAT2TSHRALDH1A1 | |
| SCHEMBL2848767 | 0.84 | HTT (0.47) | IRAK4HTTBCAT2TSHRALDH1A1 | |
| SCHEMBL5230221 | 0.83 | ACE2 (0.50) | TSHRALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL20555850 | 0.83 | ACE2 (0.50) | TSHRALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL9040914 | 0.83 | ALDH1A1 (0.43) | IRAK4TSHRALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9447033-B2 | Potassium channel blockers | JAPAN TOBACCO INC. (JP) | 2016-09-20 | — | — | US | disclosed |
| US-20150259282-A1 | Potassium Channel Blockers | XENTION LIMITED (GB) | 2015-09-17 | — | — | US | disclosed |
| US-9073834-B2 | Potassium channel blockers | XENTION LIMITED (GB) | 2015-07-07 | — | — | US | disclosed |
| US-20140221337-A1 | Potassium Channel Blockers | XENTION LIMITED (GB) | 2014-08-07 | — | — | US | disclosed |
| US-8673901-B2 | Potassium channel blockers | XENTION LIMITED (GB) | 2014-03-18 | — | — | US | disclosed |
| CN-1956946-B | Modulators of cannabinoid receptors | UCL BUSINESS PLC | 2013-07-10 | — | — | CN | disclosed |
| US-20100087428-A1 | Novel Potassium Channel Blockers | XENTION LIMITED (GB) | 2010-04-08 | — | — | US | disclosed |
| CN-1956946-A | Modulators of cannabinoid receptors | UNIV LONDON (GB) | 2007-05-02 | — | — | CN | disclosed |
| EP-0801642-B1 | NOVEL SULFAMATE COMPOUND CONTAINING N-SUBSTITUTED CARBAMOYL GROUP AND METHOD FOR PREPARING THE SAME | YUKONG LTD (KR) | 2000-12-20 | — | — | EP | disclosed |
| US-5892088-A | Sulfamate compound containing N-substituted carbamoyl group and method for preparing the same | YUKONG LIMITED (KR) | 1999-04-06 | — | — | US | disclosed |
| EP-0801642-A1 | NOVEL SULFAMATE COMPOUND CONTAINING N-SUBSTITUTED CARBAMOYL GROUP AND METHOD FOR PREPARING THE SAME | YUKONG LIMITED (KR) | 1997-10-22 | — | — | EP | disclosed |
| WO-1997016418-A1 | NOVEL SULFAMATE COMPOUND CONTAINING N-SUBSTITUTED CARBAMOYL GROUP AND METHOD FOR PREPARING THE SAME | YUKONG LIMITED (KR) | 1997-05-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221337-A1 | Potassium Channel Blockers | KCNJ2, KCNH2, KCNB1 | IRAK4 2907/4885HTT 2305/4885BCAT2 3090/4885 |
| US-20100087428-A1 | Novel Potassium Channel Blockers | HCN4, SCN2B, KCNH2 | IRAK4 2942/4885HTT 2035/4885BCAT2 2124/4885 |
| US-20150259282-A1 | Potassium Channel Blockers | KCNJ2, KCNH2, KCNB1 | IRAK4 2907/4885HTT 2305/4885BCAT2 3090/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.