Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1380696 | 0.84 | TSHR (0.55) | IRAK4HTTTSHRALDH1A1MAPT | |
| SCHEMBL8526511 | 0.84 | TSHR (0.55) | IRAK4HTTTSHRALDH1A1MAPT | |
| SCHEMBL3380036 | 0.84 | IRAK4 (0.47) | IRAK4HTTTSHRALDH1A1MAPT | |
| SCHEMBL2848767 | 0.82 | HTT (0.47) | IRAK4HTTTSHRALDH1A1MAPT | |
| SCHEMBL1003281 | 0.81 | HTT (0.46) | IRAK4HTTTSHRALDH1A1MAPT | |
| SCHEMBL105262 | 0.81 | IRAK4 (0.55) | IRAK4HTTTSHRALDH1A1MAPT | |
| SCHEMBL31632660 | 0.81 | IRAK4 (0.55) | IRAK4HTTTSHRALDH1A1MAPT | |
| Acetic Acid SCHEMBL8193458 | 0.79 | BCAT2 (0.44) | IRAK4HTTTSHRALDH1A1MAPT | |
| SCHEMBL6151172 | 0.79 | IRAK4 (0.44) | IRAK4HTTTSHRALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL7849679 | 0.79 | IRAK4 (0.53) | IRAK4HTTTSHRALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009050243-A1 | INDAZOLES AS GLUCOCORTICOID RECEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2009-04-23 | — | — | WO | disclosed |