Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.35 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6858554 | 0.86 | TSHR (0.44) | ALDH1A1TSHRACE2SMN1; SMN2MAPT | |
| SCHEMBL14216632 | 0.85 | TSHR (0.57) | ALDH1A1TSHRLMNASMN1; SMN2KDM4E | |
| SCHEMBL5230221 | 0.85 | ACE2 (0.50) | ALDH1A1TSHRACE2SMN1; SMN2KDM4E | |
| SCHEMBL20555850 | 0.85 | ACE2 (0.50) | ALDH1A1TSHRACE2SMN1; SMN2KDM4E | |
| SCHEMBL3380036 | 0.83 | IRAK4 (0.47) | ALDH1A1TSHRLMNAACE2KDM4E | |
| SCHEMBL23590684 | 0.82 | TRPV3 (0.43) | ALDH1A1TSHRKAT2BLMNAACE2 | |
| Acetic Acid SCHEMBL8193458 | 0.82 | BCAT2 (0.44) | ALDH1A1TSHRLMNAACE2KDM4E | |
| SCHEMBL1635308 | 0.81 | GABRA1 (0.50) | ALDH1A1TSHRLMNASMN1; SMN2KDM4E | |
| SCHEMBL29567244 | 0.81 | GABRA1 (0.50) | ALDH1A1TSHRLMNASMN1; SMN2KDM4E | |
| SCHEMBL24135803 | 0.81 | LMNA (0.40) | ALDH1A1TSHRKAT2BLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445731-B1 | Azabicyclo and azacyclo oxime and amine cholinergic agents and pharmaceutically acceptable salts thereof | WARNER LAMBERT CO (US) | 1996-01-10 | — | — | EP | disclosed |
| US-5482938-A | Azabicyclo and azacyclo oxime and amine cholinergic agents and methods of treatment | WARNER-LAMBERT COMPANY (US) | 1996-01-09 | — | — | US | disclosed |
| US-5346911-A | Analgesics, cognition activators, treatment of alzheimer*s s disease | WARNER-LAMBERT COMPANY (US) | 1994-09-13 | — | — | US | disclosed |
| US-5306718-A | Analgesics, cognition activators | WARNER-LAMBERT COMPANY (US) | 1994-04-26 | — | — | US | disclosed |
| EP-0445731-A1 | Azabicyclo and azacyclo oxime and amine cholinergic agents and pharmaceutically acceptable salts thereof | WARNER-LAMBERT COMPANY (US) | 1991-09-11 | — | — | EP | disclosed |