Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 15/20 | 0.64 |
| ▸ | HTR1A | P08908 | 5/20 | 0.52 |
| ▸ | HTR7 | P34969 | 5/20 | 0.52 |
| ▸ | HTR2A | P28223 | 3/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.45 |
| ▸ | HTR3B | O95264 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3826873 | 0.79 | HTR6 (1.00) | HTR6HTR1AHTR7HTR2ADRD2 | |
| SCHEMBL3378968 | 0.77 | HTR6 (0.62) | HTR6CHRNB2CHRNA4 | |
| SCHEMBL23457079 | 0.76 | HTR6 (0.66) | HTR6DRD2THRB | |
| SCHEMBL3380849 | 0.75 | HTR7 (0.54) | HTR6HTR1AHTR7CHRNB2CHRNA4 | |
| SCHEMBL5200506 | 0.73 | PIM1 (0.47) | HTR6HTR1AHTR7DRD2HTR2C | |
| SCHEMBL30476655 | 0.73 | ADRB1 (0.62) | HTR6HTR1AHTR7HTR2ADRD2 | |
| SCHEMBL3377181 | 0.72 | HTR6 (0.55) | HTR6CHRNB2CHRNA4 | |
| SCHEMBL12719397 | 0.72 | HTR6 (0.70) | HTR6HTR1AHTR7HTR2ADRD2 | |
| SCHEMBL3454087 | 0.72 | HTR6 (0.70) | HTR6HTR1AHTR7HTR2ADRD2 | |
| SCHEMBL5202316 | 0.71 | HTR6 (0.51) | HTR6HTR1AHTR7DRD2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1476428-B1 | PYRIDYL SULFONE DERIVATIVES AS 5-HT6 RECEPTOR LIGANDS | PHARMACIA & UPJOHN CO LLC (US) | 2010-11-17 | — | — | EP | claimed |