Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 14/20 | 0.55 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3378968 | 0.94 | HTR6 (0.62) | HTR6CHRNB2CHRNA4 | |
| SCHEMBL3322151 | 0.89 | HTR6 (0.68) | HTR6CHRNB2CHRNA4 | |
| SCHEMBL6488471 | 0.80 | CHRNB2 (0.58) | HTR6CHRNB2CHRNA4 | |
| SCHEMBL4520805 | 0.77 | CHRNB2 (0.55) | HTR6CHRNB2CHRNA4 | |
| SCHEMBL18553756 | 0.75 | HTR6 (0.62) | HTR6CHRNB2CHRNA4 | |
| SCHEMBL4573254 | 0.73 | HTR6 (1.00) | HTR6 | |
| SCHEMBL6745754 | 0.73 | HTR6 (0.91) | HTR6 | |
| SCHEMBL3380848 | 0.72 | HTR6 (0.64) | HTR6CHRNB2CHRNA4 | |
| SCHEMBL6745380 | 0.72 | HTR6 (0.92) | HTR6 | |
| SCHEMBL4478040 | 0.71 | HTR6 (0.50) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1476428-B1 | PYRIDYL SULFONE DERIVATIVES AS 5-HT6 RECEPTOR LIGANDS | PHARMACIA & UPJOHN CO LLC (US) | 2010-11-17 | — | — | EP | claimed |
| US-6855709-B2 | Pyridyl sulfone derivatives | PHARMACIA & UPJOHN COMPANY (US) | 2005-02-15 | — | — | US | claimed |
| EP-1476428-A1 | PYRIDYL SULFONE DERIVATIVES AS 5-HT6 RECEPTOR LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2004-11-17 | — | — | EP | claimed |
| US-20030186968-A1 | Pyridyl sulfone derivatives | PHARMACIA & UPJOHN COMPANY | 2003-10-02 | — | — | US | claimed |
| WO-2003072548-A1 | PYRIDYL SULFONE DERIVATIVES AS 5-HT RECEPTOR ANTAGONISTS | PHARMACIA & UPJOHN COMPANY (US) | 2003-09-04 | — | — | WO | claimed |
| EP-1476428-B1 | PYRIDYL SULFONE DERIVATIVES AS 5-HT6 RECEPTOR LIGANDS | PHARMACIA & UPJOHN CO LLC (US) | 2010-11-17 | — | — | EP | disclosed |
| US-6855709-B2 | Pyridyl sulfone derivatives | PHARMACIA & UPJOHN COMPANY (US) | 2005-02-15 | — | — | US | disclosed |
| EP-1476428-A1 | PYRIDYL SULFONE DERIVATIVES AS 5-HT6 RECEPTOR LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2004-11-17 | — | — | EP | disclosed |
| US-20030186968-A1 | Pyridyl sulfone derivatives | PHARMACIA & UPJOHN COMPANY | 2003-10-02 | — | — | US | disclosed |
| WO-2003072548-A1 | PYRIDYL SULFONE DERIVATIVES AS 5-HT RECEPTOR ANTAGONISTS | PHARMACIA & UPJOHN COMPANY (US) | 2003-09-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030186968-A1 | Pyridyl sulfone derivatives | HTR6, TPH1, HTR1A | HTR6 1/4885CHRNB2 589/4885CHRNA4 492/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.