Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 7/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | GLS | O94925 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 4/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | CCDC6 | Q16204 | 1/20 | 0.45 |
| ▸ | WNT3A | P56704 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3385521 | 0.89 | ALDH1A1 (0.55) | FLT3ALDH1A1KDRWNT3A | |
| SCHEMBL3385825 | 0.89 | FLT3 (0.51) | FLT3ALDH1A1KDR | |
| SCHEMBL3386448 | 0.87 | FLT3 (0.54) | FLT3ALDH1A1KDR | |
| SCHEMBL3386105 | 0.85 | ALDH1A1 (0.52) | FLT3ALDH1A1KDR | |
| SCHEMBL3386505 | 0.82 | RET (0.65) | FLT3KDRNTRK1CSF1RRET | |
| SCHEMBL3383213 | 0.78 | RET (0.55) | FLT3KDRRET | |
| SCHEMBL3385413 | 0.78 | RORC (0.48) | FLT3KDRNTRK1CSF1RRET | |
| SCHEMBL3384408 | 0.78 | KDR (0.50) | FLT3KDR | |
| SCHEMBL3385250 | 0.77 | FLT3 (0.47) | FLT3KDRNTRK1CSF1RRET | |
| SCHEMBL3386064 | 0.77 | FLT3 (0.51) | FLT3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |