Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.56 |
| ▸ | CCR3 | P51677 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 3/20 | 0.46 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3388485 | 0.99 | MAPK14 (0.56) | MAPK14CCR3ACHEHTR4SIGMAR1 | |
| SCHEMBL3388056 | 0.93 | ACHE (0.51) | ACHEKDM4EALDH1A1KMT2AHRH3 | |
| SCHEMBL3383846 | 0.91 | KDM4E (0.49) | ACHEKDM4EALDH1A1KMT2AHRH3 | |
| SCHEMBL3386876 | 0.87 | MAPK14 (0.54) | MAPK14CCR3ACHEHTR4SIGMAR1 | |
| SCHEMBL3390277 | 0.85 | MAPK14 (0.60) | MAPK14CCR3ACHEHTR4SIGMAR1 | |
| SCHEMBL3388657 | 0.84 | MAPK14 (0.60) | MAPK14CCR3ACHEHTR4SIGMAR1 | |
| SCHEMBL3383892 | 0.83 | MAPK14 (0.64) | MAPK14CCR3ACHEHTR4SIGMAR1 | |
| SCHEMBL3389729 | 0.81 | L3MBTL1 (0.43) | KDM4EALDH1A1KMT2AHRH3CNR1 | |
| SCHEMBL3390069 | 0.81 | HRH3 (0.50) | MAPK14ACHEKDM4EALDH1A1KMT2A | |
| SCHEMBL3388040 | 0.81 | DRD2 (0.49) | MAPK14CCR3ACHEHTR4CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029534-B1 | 1H-INDOL-5-YL-PIPERAZIN-1-YL-METHANONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-12-22 | — | — | EP | disclosed |
| CN-101443311-A | 1H-indol-5-yl-piperazin-1-yl-methanone derivatives | HOFFMANN LA ROCHE (CH) | 2009-05-27 | — | — | CN | disclosed |