Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | CFTR | P13569 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3393250 | 0.90 | MAPK12 (0.40) | PTK2BGAAKMT2AKDM4EALDH1A1 | |
| SCHEMBL3393224 | 0.90 | GBA1 (0.38) | JAK2PTK2BGAAKMT2AKDM4E | |
| SCHEMBL3389419 | 0.90 | ALDH1A1 (0.39) | JAK2PTK2BGAAKMT2AKDM4E | |
| SCHEMBL3391110 | 0.90 | GBA1 (0.41) | — | |
| SCHEMBL3394251 | 0.88 | PTK2B (0.39) | PTK2BKMT2AKDM4EALDH1A1HTT | |
| SCHEMBL3422290 | 0.88 | MAPK14 (0.37) | PTK2BGAAKMT2AKDM4EALDH1A1 | |
| SCHEMBL3392100 | 0.87 | PTK2B (0.39) | PTK2BKMT2ALMNATSHRMAPK14 | |
| SCHEMBL3394262 | 0.86 | GAA (0.38) | PTK2BGAAKMT2AKDM4EALDH1A1 | |
| SCHEMBL3394297 | 0.86 | PTK2B (0.40) | PTK2BKMT2AKDM4EALDH1A1HTT | |
| SCHEMBL3180430 | 0.86 | CDK8 (0.35) | PTK2BMAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943243-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2010-12-29 | — | — | EP | disclosed |