Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3391158 | 0.93 | GBA1 (0.37) | GBA1KDM4EGAAALDH1A1HTT | |
| SCHEMBL3393213 | 0.93 | PTK2B (0.38) | KDM4ESMN1; SMN2PTK2BMAPK14HSD17B10 | |
| SCHEMBL3389419 | 0.92 | ALDH1A1 (0.39) | KDM4EGAAALDH1A1PTK2BKMT2A | |
| SCHEMBL3393250 | 0.92 | MAPK12 (0.40) | GBA1KDM4EGAAALDH1A1HTT | |
| SCHEMBL3391110 | 0.91 | GBA1 (0.41) | GBA1DCTPP1 | |
| SCHEMBL3389769 | 0.90 | JAK2 (0.37) | KDM4EGAAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL3394251 | 0.90 | PTK2B (0.39) | GBA1KDM4EALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL3422290 | 0.90 | MAPK14 (0.37) | GBA1KDM4EGAAALDH1A1HTT | |
| SCHEMBL3392554 | 0.89 | PTK2B (0.37) | KDM4EALDH1A1HTTSMN1; SMN2PTK2B | |
| SCHEMBL3392100 | 0.89 | PTK2B (0.39) | PTK2BKMT2AMAPK14LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943243-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2010-12-29 | — | — | EP | disclosed |