Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KHK | P50053 | 1/20 | 0.38 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | BRAF | P15056 | 2/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | HCK | P08631 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3394251 | 0.90 | PTK2B (0.39) | KDM4EHTTSMN1; SMN2ALDH1A1PTK2B | |
| SCHEMBL3392100 | 0.89 | PTK2B (0.39) | PTK2BLMNAKMT2AMAPK12MAPK14 | |
| SCHEMBL3389419 | 0.88 | ALDH1A1 (0.39) | GAAKDM4EALDH1A1PTK2BLMNA | |
| SCHEMBL3393224 | 0.88 | GBA1 (0.38) | GAAKDM4EHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL3393250 | 0.88 | MAPK12 (0.40) | GAAKDM4EHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL3394297 | 0.88 | PTK2B (0.40) | KDM4EHTTSMN1; SMN2ALDH1A1PTK2B | |
| SCHEMBL3180430 | 0.88 | CDK8 (0.35) | PTK2BMAPK12MAPK14BRAF | |
| SCHEMBL3391110 | 0.87 | GBA1 (0.41) | — | |
| SCHEMBL3393213 | 0.87 | PTK2B (0.38) | KDM4ESMN1; SMN2PTK2BLMNAMAPK12 | |
| SCHEMBL3174404 | 0.87 | MAPK14 (0.38) | HTTALDH1A1PTK2BLMNAMAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943243-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2010-12-29 | — | — | EP | disclosed |