Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2344346 | 0.96 | TSHR (0.52) | TSHRCYP3A4TDP1ALDH1A1CYP1A2 | |
| SCHEMBL29536425 | 0.96 | TSHR (0.52) | TSHRCYP3A4TDP1ALDH1A1CYP1A2 | |
| SCHEMBL2374034 | 0.89 | TSHR (0.52) | TSHRCYP3A4TDP1ALDH1A1CYP1A2 | |
| SCHEMBL9652342 | 0.83 | TSHR (0.57) | TSHRCYP3A4TDP1ALDH1A1CYP1A2 | |
| SCHEMBL30578459 | 0.81 | TSHR (0.59) | TSHRCYP3A4TDP1ALDH1A1CYP1A2 | |
| SCHEMBL348272 | 0.81 | TSHR (0.59) | TSHRCYP3A4TDP1ALDH1A1CYP1A2 | |
| SCHEMBL7653551 | 0.81 | ALDH1A1 (0.53) | TSHRCYP3A4TDP1ALDH1A1CYP1A2 | |
| SCHEMBL11219818 | 0.81 | TSHR (0.59) | TSHRCYP3A4TDP1ALDH1A1CYP1A2 | |
| SCHEMBL13609636 | 0.79 | ALDH1A1 (0.52) | TSHRCYP3A4TDP1ALDH1A1CYP1A2 | |
| SCHEMBL1198631 | 0.79 | CYP1A2 (0.52) | TSHRCYP3A4TDP1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010052448-A2 | FUSED PYRAZINE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2010-05-14 | — | — | WO | disclosed |