Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | NPY2R | P49146 | 1/20 | 0.38 |
| ▸ | CCKAR | P32238 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | BCR | P11274 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3394297 | 0.93 | PTK2B (0.40) | ALDH1A1HPGDKMT2APTK2BMAPK14 | |
| SCHEMBL3393248 | 0.93 | MAPT (0.43) | ALDH1A1CA12CA1CA2CA9 | |
| SCHEMBL3392554 | 0.92 | PTK2B (0.37) | ALDH1A1CA12CA1CA2CA7 | |
| SCHEMBL3393200 | 0.92 | PTK2B (0.37) | ALDH1A1NAMPTCA12CA1CA2 | |
| SCHEMBL3394251 | 0.91 | PTK2B (0.39) | ALDH1A1KMT2APTK2BMAPK14BRAF | |
| SCHEMBL3391076 | 0.91 | PHGDH (0.40) | ALDH1A1NPY2RKMT2APTK2BMAPK14 | |
| SCHEMBL3392100 | 0.89 | PTK2B (0.39) | KMT2APTK2BMAPK14BRAFSRC | |
| SCHEMBL3389398 | 0.88 | PTK2B (0.36) | KMT2APTK2BMAPK14BRAFSRC | |
| SCHEMBL3389419 | 0.88 | ALDH1A1 (0.39) | ALDH1A1NAMPTNPY2RKMT2APTK2B | |
| SCHEMBL3394286 | 0.88 | LMNA (0.37) | ALDH1A1KMT2APTK2BMAPK14BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943243-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2010-12-29 | — | — | EP | disclosed |