Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trinitrophenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.64 |
| ▸ | ESR1 | P03372 | 6/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
| ▸ | SCN1A | P35498 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trinitrophenol SCHEMBL339138 | 1.00 | LMNA (0.64) | LMNACYP1A2CYP3A4TSHRCYP2C19 | |
| Trinitrophenol SCHEMBL7554611 | 0.88 | NPC1 (0.62) | LMNACYP1A2CYP3A4ESR1ALDH1A1 | |
| Trinitrophenol SCHEMBL4189273 | 0.82 | ALDH1A1 (0.65) | LMNACYP3A4TSHRESR1ALDH1A1 | |
| SCHEMBL10946509 | 0.81 | ESR1 (0.61) | LMNACYP1A2CYP3A4TSHRCYP2C19 | |
| SCHEMBL3391559 | 0.80 | PKM (0.66) | LMNACYP1A2CYP3A4TSHRCYP2C19 | |
| Butamben SCHEMBL81735 | 0.80 | LMNA (1.00) | LMNACYP1A2CYP3A4TSHRCYP2C19 | |
| Butamben SCHEMBL27614630 | 0.78 | LMNA (0.97) | LMNACYP1A2CYP3A4TSHRCYP2C19 | |
| Butamben SCHEMBL28512544 | 0.78 | LMNA (0.97) | LMNACYP1A2CYP3A4TSHRCYP2C19 | |
| SCHEMBL11495159 | 0.78 | ESR1 (0.57) | LMNACYP1A2CYP3A4TSHRCYP2C19 | |
| SCHEMBL9762616 | 0.78 | TDP1 (0.57) | TSHRESR1ALDH1A1NPC1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1117 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210046040-A1 | PAIN-RELIEVING TOPICAL COMPOSITIONS | INNOCAN PHARMA LTD. (IL) | 2021-02-18 | — | — | US | claimed |
| EP-3735225-A1 | PAIN-RELIEVING TOPICAL COMPOSITIONS | INNOCAN PHARMA LTD. (IL) | 2020-11-11 | — | — | EP | claimed |
| WO-2020012480-A1 | PAIN-RELIEVING TOPICAL COMPOSITIONS | INNOCAN PHARMA LTD. (IL) | 2020-01-16 | — | — | WO | claimed |
| US-20190224105-A9 | COMPOUND, COMPOSITION, AND METHOD FOR PROTECTING SKIN FROM HIGH ENERGY VISIBLE LIGHT | PHOTOPROTECTIVE TECHNOLOGIES, INC. (US) | 2019-07-25 | — | — | US | claimed |
| US-20190008306-A1 | COMPOUND, COMPOSITION, AND METHOD FOR PROTECTING SKIN FROM HIGH ENERGY VISIBLE LIGHT | PHOTOPROTECTIVE TECH INC (US) | 2019-01-10 | — | — | US | claimed |
| US-20180361032-A1 | IMPLANTABLE ELECTROSPUN PATCHES FOR SITE-DIRECTED DRUG DELIVERY | THE METHODIST HOSPITAL | 2018-12-20 | — | — | US | claimed |
| US-20160317425-A1 | COMPOUND, COMPOSITION, AND METHOD FOR PROTECTING SKIN FROM HIGH ENERGY VISIBLE LIGHT | PHOTOPROTECTIVE TECHNOLOGIES, INC. (US) | 2016-11-03 | — | — | US | claimed |
| US-20140348787-A1 | Methods and Compositions for Treating Ear Infections | PROFESSIONAL COMPOUNDING CENTERS OF AMERICA (US) | 2014-11-27 | — | — | US | claimed |
| US-20140296826-A1 | PREPARATION PATCH AND SAFETY SYRINGE SYSTEM | COVIDIEN LP (US) | 2014-10-02 | — | — | US | claimed |
| EP-2777719-A2 | Preparation Patch and Safety Syringe System | Covidien LP (US) | 2014-09-17 | — | — | EP | claimed |
| CN-1058150-C | Topical aromatic releasing compositions | RICHARD VICKS INC (US) | 2000-11-08 | — | — | CN | claimed |
| WO-2000041528-A2 | IMPROVED CONTROLLED RELEASE COMPOSITIONS AND METHOD | AMCOL INTERNATIONAL CORPORATION (US) | 2000-07-20 | — | — | WO | claimed |
| WO-2000038617-A2 | COMPOSITIONS AND METHODS OF USING THE SAME | FOUR STAR PARTNERS (US) | 2000-07-06 | — | — | WO | claimed |
| US-5814659-A | ANALGESIC, ALCOHOL, CHAOTROPIC AGENT AND UNSATURATED FATTY ACID | DTR DERMAL THERAPY (BARBADOS) INC. (BB) | 1998-09-29 | — | — | US | claimed |
| EP-0727978-A4 | TOPICAL AROMATIC RELEASING COMPOSITIONS | RICHARDSON VICKS INC (US) | 1997-01-29 | — | — | EP | claimed |
| EP-0727978-A1 | TOPICAL AROMATIC RELEASING COMPOSITIONS | RICHARDSON-VICKS, INC. (US) | 1996-08-28 | — | — | EP | claimed |
| US-5322689-A | Topical aromatic releasing compositions | THE PROCTER & GAMBLE COMPANY (US) | 1994-06-21 | — | — | US | claimed |
| CN-1079896-A | The compositions of topical aromatic releasing | RICHARDSON VICKS INC (US) | 1993-12-29 | — | — | CN | claimed |
| WO-1993017655-A1 | TOPICAL AROMATIC RELEASING COMPOSITIONS | RICHARDSON VICKS INC. (US) | 1993-09-16 | — | — | WO | claimed |
| US-4312865-A | Medication having penetration through cutaneous surfaces into articular and muscular areas | SZUCS MURRILL M | 1982-01-26 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190224105-A9 | COMPOUND, COMPOSITION, AND METHOD FOR PROTECTING SKIN FROM HIGH ENERGY VISIBLE LIGHT | CUTA, TYR, XPA | LMNA 549/4885CYP1A2 113/4885CYP3A4 268/4885 |
| US-20160317425-A1 | COMPOUND, COMPOSITION, AND METHOD FOR PROTECTING SKIN FROM HIGH ENERGY VISIBLE LIGHT | CUTA, TYR, XPA | LMNA 549/4885CYP1A2 113/4885CYP3A4 268/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.