Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | ILK | Q13418 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | ADK | P55263 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8297950 | 0.86 | MEN1 (0.46) | KDM4EGSK3BADKMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL27450739 | 0.85 | MEN1 (0.44) | KDM4EGSK3BADKMEN1KMT2A | |
| SCHEMBL13735546 | 0.80 | IDO1 (0.33) | MEN1KMT2A | |
| SCHEMBL11745392 | 0.77 | DHFR (0.46) | KDM4EGAAGSK3BMEN1KMT2A | |
| SCHEMBL27714735 | 0.76 | PTPN11 (0.43) | ALDH1A1 | |
| SCHEMBL954343 | 0.76 | BCAT2 (0.47) | CDC7KDM4EGSK3BALDH1A1LCK | |
| SCHEMBL28501811 | 0.75 | PARP1 (0.46) | CDC7ALOX5ILKKDM4EGAA | |
| SCHEMBL8301453 | 0.75 | GSK3B (0.41) | KDM4EGSK3BADKMEN1KMT2A | |
| Carbamic Acid SCHEMBL31151006 | 0.74 | ALOX5 (0.54) | ALOX5KDM4EGAAMEN1KMT2A | |
| SCHEMBL5849850 | 0.72 | BCAT2 (0.55) | CDC7ALOX5KDM4EGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-7278114-A | — | — | None | — | — | JP | disclosed |
| EP-1487802-B1 | 2,3-Diaryl-pyrazolidine derivatives as neurotensin degrading enzyme inhibitors | ABBOTT HEALTHCARE PRODUCTS BV (NL) | 2010-12-29 | — | — | EP | disclosed |
| US-5955474-A | ANTIEDEMA AGENTS OR DIURETIC ANTAGONIST | SANOFI (FR) | 1999-09-21 | — | — | US | disclosed |
| EP-0647629-B1 | Neurotensin active substituted 1-naphthylpyrazole-3-carboxamides, their preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1999-07-07 | — | — | EP | disclosed |
| US-5585497-A | USEFUL IN TREATMENT OF NEUROPSYCHIATRIC DISORDERS, ESPECIALLY THOSE ASSOCIATED WITH A DYSFUNCTION OF THE DOPAMINERGIC SYSTEMS | SANOFI (FR) | 1996-12-17 | — | — | US | disclosed |
| US-5585497-A | USEFUL IN TREATMENT OF NEUROPSYCHIATRIC DISORDERS, ESPECIALLY THOSE ASSOCIATED WITH A DYSFUNCTION OF THE DOPAMINERGIC SYSTEMS | SANOFI (FR) | 1996-12-17 | — | — | US | disclosed |
| US-5523455-A | PREPARED USING A NAPHTHYLHYDRAZINE CHEMICAL INTERMEDIATE | SANOFI (FR) | 1996-06-04 | — | — | US | disclosed |
| US-5523455-A | PREPARED USING A NAPHTHYLHYDRAZINE CHEMICAL INTERMEDIATE | SANOFI (FR) | 1996-06-04 | — | — | US | disclosed |
| US-5502059-A | DOPAMINERGIC DYSFUNCTION DISORDERS | SANOFI (FR) | 1996-03-26 | — | — | US | disclosed |
| US-5502059-A | DOPAMINERGIC DYSFUNCTION DISORDERS | SANOFI (FR) | 1996-03-26 | — | — | US | disclosed |
| US-5502059-A | DOPAMINERGIC DYSFUNCTION DISORDERS | SANOFI (FR) | 1996-03-26 | — | — | US | disclosed |
| EP-0699438-A2 | Use of neurotensin antagonists for the preparation of diuretic drugs | SANOFI (FR) | 1996-03-06 | — | — | EP | disclosed |
| JP-H07278114-A | SUBSTITUTED 1-NAPHTHYL-3-PYRAZOLECARBOXAMIDE WHICH IS ACTIVE ON NEUROTENSIN, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | SANOFI SA | 1995-10-24 | — | — | JP | disclosed |
| CN-1108651-A | Substituted 1-naphthyl-3-pyrazolecarboxamides which are actie on neurotensin, their preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1995-09-20 | — | — | CN | disclosed |
| CN-1108651-A | Substituted 1-naphthyl-3-pyrazolecarboxamides which are actie on neurotensin, their preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1995-09-20 | — | — | CN | disclosed |
| CN-1108651-A | Substituted 1-naphthyl-3-pyrazolecarboxamides which are actie on neurotensin, their preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1995-09-20 | — | — | CN | disclosed |
| EP-0647629-A1 | Neurotensin active substituted 1-naphthylpyrazole-3-carboxamides, their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1995-04-12 | — | — | EP | disclosed |
| EP-0647629-A1 | Neurotensin active substituted 1-naphthylpyrazole-3-carboxamides, their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1995-04-12 | — | — | EP | disclosed |