Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT1 | Q99873 | 6/20 | 0.62 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3395850 | 0.85 | PRMT1 (0.59) | PRMT1SCN10APRMT6ABCB1SLC6A4 | |
| SCHEMBL3423840 | 0.83 | SLC6A4 (0.50) | PRMT6SLC6A4TSHRALDH1A1ACHE | |
| SCHEMBL13070333 | 0.83 | SLC6A4 (0.50) | PRMT6SLC6A4TSHRALDH1A1ACHE | |
| SCHEMBL3709650 | 0.78 | PRMT1 (0.51) | PRMT1SCN10APRMT6ABCB1TSHR | |
| Hydrochloric Acid SCHEMBL3398629 | 0.77 | PRMT1 (0.52) | PRMT1SCN10APRMT6ABCB1TSHR | |
| SCHEMBL3396194 | 0.77 | PRMT6 (0.40) | PRMT1SCN10APRMT6SLC6A4TSHR | |
| SCHEMBL13074386 | 0.76 | SLC6A4 (0.57) | PRMT1PRMT6SLC6A4TSHRALDH1A1 | |
| SCHEMBL3392210 | 0.76 | PRMT1 (0.47) | PRMT1SCN10ATSHRALDH1A1MAPT | |
| Trifluoroacetic Acid SCHEMBL3398116 | 0.74 | PRMT1 (0.47) | PRMT1SCN10AABCB1ALDH1A1MAPT | |
| SCHEMBL3398119 | 0.74 | PRMT1 (0.46) | PRMT1SCN10AABCB1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | disclosed |
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | disclosed |
| WO-2010081904-A1 | 4 ( 1H) -PYRIDINONE DERIVATIVES AND THEIR USE AS ANTIMALARIA AGENTS | GLAXO GROUP LIMITED (GB) | 2010-07-22 | — | — | WO | disclosed |