Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 13/20 | 0.50 |
| ▸ | MAOA | P21397 | 5/20 | 0.50 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | MMP14 | P50281 | 1/20 | 0.44 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19538689 | 0.81 | TSHR (0.60) | EPHX2DRD2FAAH | |
| SCHEMBL4564168 | 0.77 | L3MBTL1 (0.47) | EPHX2FAAH | |
| SCHEMBL14438091 | 0.76 | HTR2A (0.53) | MAOBEPHX2DRD2FAAH | |
| SCHEMBL81671 | 0.76 | MAOB (0.60) | MAOBMAOADRD2 | |
| SCHEMBL3392222 | 0.76 | MAOA (0.58) | MAOBMAOADRD2 | |
| SCHEMBL22816265 | 0.75 | EPHX2 (0.38) | EPHX2FAAH | |
| SCHEMBL3398473 | 0.75 | TEAD1 (0.57) | DRD2 | |
| SCHEMBL3392273 | 0.75 | FAAH (0.39) | EPHX2DRD2FAAH | |
| SCHEMBL28247613 | 0.73 | MEN1 (0.48) | EPHX2FAAH | |
| SCHEMBL64479 | 0.73 | MAOB (0.48) | MAOBMAOAP2RY14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | disclosed |